What is Precision Medicine?
Precision medicine is healthcare customized to each individual and their custom needs. Your age, lifestyle, and your genetic make-up all influence your response to medications. An area of Precision medicine is Pharmacogenomics.
Pharmacogenomics is the study how of a person's unique genetic make-up, the entire genome, influences their response to medications. Pharmacogenomics aims to change the standard approach of medicine, it just doesn't work for everyone.
What is Pharmacogenomics?
Pharmacogenomics is the study how of a person's unique genetic make-up, the entire genome, influences their response to medications. Pharmacogenomics aims to change the standard approach of medicine, it just doesn't work for everyone.
Why is genomic information helpful?
Your genes are the blueprint for how every cell will operate, this includes what proteins a cell will make and how they will make them. Changes in your genetic blueprint can change how a protein functions or if its even made at all. In medicine, a particular protein could play a major role in drug treatment. Some major roles proteins play in drug function are:
The protein plays a role in metabolizing the drug.
The protein plays a role in absorption or transportation of the drug.
The protein is targeted by the drug.
The protein is involved in a multi-series molecular event that is triggered by the drug.
Pharmacogenomics aims to compare the genomes of individuals taking the same drug and discover genetic variants among them that could influence their response to a drug. These variants can effect their risk of side effects, they may need a higher dose, or the treatment may not work at all.
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6. Frequenty asked questions about pharmacogenomics. National Human Genome Research Institute. http://www.genome.gov/27530645. Accessed Jan. 9, 2020.
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9. Precision medicine: What does it mean for your health? Centers for Disease Control and Prevention. https://www.cdc.gov/features/precision-medicine/. Accessed Jan. 9, 2020.
2. Godman B, et al. Personalizing health care: Feasibility and future implications. BMC Medicine. 2013;11:179.
3. Tremblay J, et al. Role of genomics on the path to personalized medicine. Metabolism. 2013;62(suppl):S2.
4. Wang L, et al. Genomics and drug response. New England Journal of Medicine. 2011;364:1144.
5. Weinshilboum RM, et al. Pharmacogenomics: Precision medicine and drug response. Mayo Clinic Proceedings. 2017;92:1711.
6. Frequenty asked questions about pharmacogenomics. National Human Genome Research Institute. http://www.genome.gov/27530645. Accessed Jan. 9, 2020.
7. Pharmacogenomics. National Institute of General Medical Sciences. https://www.nigms.nih.gov/education/Pages/factsheet-pharmacogenomics.aspx. Accessed Jan. 9, 2020.
8. Barbara Woodward Lips Patient Education Center. What you need to know about pharmacogenomic testing. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018.
9. Precision medicine: What does it mean for your health? Centers for Disease Control and Prevention. https://www.cdc.gov/features/precision-medicine/. Accessed Jan. 9, 2020.