1. Martinez KL, Klein A, Martin JR, Sampson CU, Giles JB, Beck ML, Bhakta K, Quatraro G, Farol J, Karnes JH. Disparities in ABO Blood Type Determination Across Diverse Ancestries: A Systematic Review and Validation in the All of Us Research Program. JAMIA. 2024 [In Press]
2. Baskir R, Lee M, McMaster S, Lee J, Blackburne-Proctor F, Azuine R, Mack N, Schully SD, Mendoza M, Sanchez J, Crosby Y, Zumba E, Hahn M, Aspaas N, Elmi A, Alerte S, Stewart E, Wilfong D, Doherty M, Farrell MM, Hébert MGB, Hood S, Thomas C, Murray D, Lee B, Karnes JH, Stark LA, Lewis MA, Uhrig JD, Bartlett L, Rico EG, Falcón A, Cohn E, Lunn MR, Obedin-Maliver J, Eder M, Cottler LB, Randall FT, Lemieux KT, Lemieux N, Lemieux N, Bradley L, Rodriguez M, Wilson M, Tepp R, Lunt C, Watson K. Research for All: Building a Diverse Researcher Community for the All of Us Research Program. JAMIA. 2024:ocae270.
3. Empey PE, Karnes JH, Johnson JA. Pharmacogenetics: Opportunities for the All of Us Research Program and Other Large Data Sets to Advance the Field. Annu Rev Pharmacol Toxicol. 2024 [In Press]
4. El Rouby N, Singh S, Stocco G, Theken K, Dickson A, Feng Q, Karnes J, Mosley J. Pharmacogenomics Polygenic Risk score: Ready or Not for Prime Time? Clin Transl Sci. 2024 [In Press]
5. Giles JB, Martinez KL, Steiner HE, Klein A, Ooi A, Pryor J, Sweitzer N, Fuchs D, Karnes JH. Association of Metal Cations with the Anti-PF4/Heparin Antibody Response in Heparin-Induced Thrombocytopenia. Cardiovasc Toxicol. 2024; 24(9):968-981. PMC10528503 PubMed Link
6. Tang H, Gupta A, Morrisroe S, Bao C, Schwantes-An TH, Gupta G, Liang S, Sun Y, Chu A, Luo A, Elangovan VR, Sangam S, Shi Y, Naidu S, Jheng JR, Ciftci-Yilmaz S, Warfel N, Hecker L, Mitra S, Coleman A, Lutz K, Pauciulo M, Lai YC, Javaheri A, Dharmakumar R, Wu WH, Flaherty D, Karnes J, Breuils-Bonnet S, Boucherat O, Bonnet S, Yuan J, Jacobson J, Duarte J, Nichols W, Garcia J, and Desai A. Deficiency of the Deubiquitinase, UCHL1, Attenuates Pulmonary Hypertension. Circulation. 2024 [In Press]
7. Jafari E, Blackman M, Karnes J, Van Driest S, Crawford D, Choi L, and McDonough C. Using Electronic Health Records for Clinical Pharmacology Research: Challenges and Considerations. Clin Transl Sci. 2024; 17(7):e13871. PMCID: PMC11213823 PubMed Link
8. Venner E, Patterson K, Kalra D, Wheeler M, Chen YJ, Kalla S, Yuan B, Karnes J, Walker K, Smith J, McGee S, Radhakrishnan A, Haddad A, Empey P, Wang Q, Lichtenstein L, Toledo D, Jarvik G, Musick A, Gibbs R, on behalf of the All of Us Research Program Investigators. The Frequency of Pathogenic Variation in the All of Us Cohort Reveals Ancestry-driven Disparities. Commun Biol. 2024; 19;7(1):174. PMCID: PMC10876563. PubMed Link
9. Tai YY, Yu Q, Tang Y, Sun W, Kelly N, Okawa S, Zhao J, Schwantes-An TH, Lacoux C, Torrino S, Al Aaraj Y, El Khoury W, Negi V, Liu M, Corey C, Belmonte F, Vargas S, Schwartz B, Bhat B, Chau B, Karnes JH, Satoh T, Barndt R, Wu H, Parikh V, Wang J, Zhang Y, McNamara D, Li G, Speyer G, Wang B, Shiva S, Kaufman BA, Kim S, Gomez D, Mari B, Cho M, Boueiz A, Pauciulo M, Southgate L, Trembath R, Sitbon O, Humbert M, Gräf S, Morrell N, Rhodes C, Wilkins M, Nouraie SM, Nichols W, Desai A, Bertero T, Chan SY. Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension. Sci Transl Med. 2024; 10;16(729):eadd2029. PMCID: PMC10947529 PubMed Link
10. Miller E, Sampson CUO, Desai AA, Karnes JH. Differential Drug Response in Pulmonary Arterial Hypertension: The Potential for Precision Medicine. Pulm Circ. 2023; 13(4):e12304. PMCID: PMC10621006. PubMed Link
11. Giles JB, Rollin J, Martinez KL, Selleng K, Thiele T, Pouplard C, Sheppard JI, Heddle NM, Phillips EJ, Roden DM, Gruel Y, Warkentin TE, Greinacher A, Karnes JH. Laboratory and Demographic Predictors of Functional Assay Positive Status in Suspected Heparin-Induced Thrombocytopenia: A Multicenter Retrospective Cohort Study. Thromb Res. 2023; 229:198-208. PMCID: PMC10528503. PubMed Link
12. Casanova NG, Chiang SM, Gonzalez-Garay ML, Batai K, Garman L, Montgomery CG, Ellis N, Kittles R, Bime C, Hsu A, Holland S, Lussier Y, Karnes J, Sweiss N, Maier LA, Koth L, Moller D, Kaminski N, Garcia JGN. Examination of eQTL Polymorphisms Associated with Increased Risk of Progressive Complicated Sarcoidosis in European and African Descent Subjects. Eur J Respir Med. 2023; 5(1):359-371. PMCID: PMC10883688. PubMed Link
13. Lynn H, Sun X, Casanova N, Bime C, Reyes-Hernon V, Lanham C, Oita R, Ramos N, Sun B, Coletta D, Camp S, Karnes JH, Ellis N, Garcia JGN. Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels and ARDS severity. Ther Adv Respir Dis. 17:17534666231181262. 2023 PMCID: PMC10363883. PubMed Link
14. Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu Q, Zagorski J, Morrisroe SA, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics. Am J Respir Crit Care Med. 2023; 207(8):1055-1069. PMCID: PMC10112457. PubMed Link
15. Feng J, Astiazaran-Symonds E, and Karnes JH. Visualization and Quantification of the Association Between Breast Cancer and Cholesterol in the All of Us Research Program. Cancer Inform. 2023; 22:11769351221144132. PMCID: PMC9841847. PubMed Link
16. Steiner HE, Carrion KC, Giles JB, Lima AR, Yee K, Sun X, Cavallari L, Perera M, Duconge J, Karnes JH. Local Ancestry-Informed Candidate Pathway Analysis of Warfarin Stable Dose in Latino Populations. Clin Pharmacol Ther. 2023; 113(3):680-691. PMCID: PMC9957812 PubMed Link
17. Steiner HE, Patterson HK, Giles JB, Karnes JH. Bringing Pharmacomicrobiomics to the Clinic Through Well-Designed Studies. Clin Transl Sci. 2022; 15(10):2303-2315. PMCID: PMC9579385PubMed Link
18. Giles JB, Steiner HE, Rollin J, Shaffer CM, Momozawa Y, Mushiroda T, Inai C, Selleng K, Thiele T, Pouplard C, Heddle NM, Kubo M, Miller EC, Martinez KL, Phillips EJ, Warkentin TE, Gruel Y, Greinacher A, Roden DM, Karnes JH. Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia. Blood Adv. 2022; 6(14):4137-4146. PMCID: PMC9327558. PubMed Link
19. Karnes JH, Rollin J, Giles JB, Martinez KL, Steiner HE, Shaffer CM, Momozawa Y, Inai C, Bombin A, Shi M, Mosley JD, Stanaway I, Selleng K, Thiele T, Mushiroda T, Pouplard C, Heddle NM, Kubo M, Phillips EJ, Warkentin TE, Gruel Y, Greinacher A, Roden DM. ABO O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia. Blood. 2022; 140(3):274-284. PMCID: PMC9305089. PubMed Link
20. Harbaum L, Rhodes CJ, Wharton J, Lawrie A, Karnes JH, Desai AA, Nichols WC, Humbert M, Montani D, Girerd B, Sitbon O, Boehm M, Novoyatleva T, Schermuly RT, Ghofrani HA, Toshner M, Kiely DG, Howard LS, Swietlik EM, Gräf S, Pietzner M, Morrell NW, Wilkins MR. Mining the plasma proteome for insights into the molecular pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2022; 205(12):1449-1460. PMCID: PMC9875902. PubMed Link
21. Karnes JH, Asempa T, Barreto J, Belcher RM, Bissell BD, Gamma RS, Kier KL, Lee CR, Liu L, McCune JS, Minhaj FS, Newsome AS, Ning J, Bookstaver PB. The Essential Research Curriculum for Doctor of Pharmacy Degree Programs: 2021 Update. J Am Coll Clin Pharm. 2022; 30(9):966. PMCID: PMC3061314. PubMed Link
22. Giles JB, Miller EC, Steiner HE, Karnes JH. Elucidation of Cellular Contributions to Heparin-Induced Thrombocytopenia Using Omic Approaches. Front Pharmacol. 2022; 12:812830. PMCID: PMC8814424 PubMed Link
23. Miller E, Norwood C, Giles JB, Huddart R, Karnes JH, Whirl-Carrillo M, Klein TE. PharmGKB Summary: Heparin Induced Thrombocytopenia (HIT) Pathway. Pharmacogenet Genomics. 2022; 32(3):117-124. PMCID: PMC8988468. PubMed Link
24. Steiner HE, Gee K, Giles J, Knight H, Hurwitz BL, Karnes JH. Role of the Gut Microbiome in Cardiovascular Drug Response: The Potential for Clinical Application. Pharmacotherapy 2021; 42(2):165-176. PMCID: PMC10321137. PubMed Link
25. Baxter SL, Saseendrakumar BR, Paul P, Kim J, Bonomi L, Kuo TT, Loperena R, Ratsimbazafy F, Boerwinkle E, Cicek M, Clark CR, Cohn E, Gebo K, Mayo K, Mockrin S, Schully SD, Ramirez A, Ohno-Machado L; All of Us Research Program Investigators (listed 42 out of 95 investigators). Predictive Analytics for Glaucoma Using Data From the All of Us Research Program. Am J Ophthalmol. 2021; 227:74-86. PMCID: PMC8184631. PubMed Link
26. Steiner HE, Giles JB, Patterson HK, Feng J, Rouby NE, Claudio K, Marcatto LR, Tavares LC, Galvez JM, Calderon-Ospina CA, Sun X, Hutz MH, Scott S, Cavallari LH, Fonseca DJ, Duconge J, Botton MR, Santos PCJL, Karnes J. Machine Learning for Prediction of Stable Warfarin Dose in US Latinos and Latin Americans. Front Pharmacol. 2021; 12:749786. PMCID: PMC8585774 PubMed Link
27. Karnes JH, Arora A, Feng J, Steiner HE, Sulieman L, Boerwinkle E, Clark C, Cicek M, Cohn E, Gebo K, Loperena-Cortes R, Ohno-Machado L, Mayo K, Mockrin S, Ramirez A, Schully S, Klimentidis YC, on behalf of the All of Us Research Program Investigators. Racial, Ethnic, and Gender Differences in Obesity and Body Fat Distribution: an All of Us Research Program Demonstration Project. Plos One. 2021; 16(8):e0255583. PMCID: PMC8345840 PubMed Link
28. Clark CR, Chandler PD, Zhou G, Noel N, Achille C, Mendez L, Karnes JH, Klimentidis YC, Jordan CD, Hiatt R, Ramirez AH, Loperena R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Schully S, Mockrin S, Gebo K, Karlson EW on behalf of the All of Us Research Program Investigators. Geographic Variation in Obesity at the State-Level in the All of Us Research Program. Prev Chronic Dis. 2021; 18:E104. PMCID: PMC8718125 PubMed Link
29. Grace C, Larriva MM, Steiner HE, Marupuru S, Campbell PJ, Patterson H, Cropp C, Quinn D, Klimecki W, Nix DE, Warholak T, Karnes JH. Efficacy of Personal Pharmacogenomic Testing as an Educational Tool in the Pharmacy Curriculum: A Non-Blinded, Randomized Controlled Trial. Clin Transl Sci. 2021; 14(6):2532-2543. PMCID: PMC8604226 PubMed Link
30. Toshner M, Church C, Harbaum L, Rhodes C, Villar S, Liley J, Jones R, Arora A, Batai K, Desai A, Coghlan J, Gibbs JS, Gor D, Gräf, S, Harlow L, Hernandez-Sanchez J, Howard L, Humbert M, Karnes J, Kiely D, Kittles R, Knightbridge E, Lam B, Lutz K, Nichols B, Pauciulo M, Pepke-Zaba J, Suntharalingam J, Soubrier F, Trembath R; Schwantes-An T-H, Wort S, Wilkins M, Gaine S, Morrell N, Corris P. Mendelian randomization and experimental medicine trial fail to support IL-6 as a drug target in pulmonary arterial hypertension. Eur Respir J. 2022; 59(3):2002463. PMCID: PMC8907935 PubMed Link
31. Deshpande P, Hertzman RJ, Palubinsky AM, Giles JB, Karnes JH, Gibson A, Phillips EJ. Immunopharmacogenomics: Mechanisms of hla-associated drug reactions. Clin Pharmacol Ther. 2021;110(3):607-15. Epub 2021/06/19. doi: 10.1002/cpt.2343. PubMed PMID: 34143437; PMCID: PMC8500648.PubMed Link
32. Cronin RM, Halvorson AE, Springer C, Feng X, Sulieman L, Loperena-Cortes R, Mayo K, Carroll RJ, Chen Q, Ahmedani BK, Karnes J, Korf B, O'Donnell CJ, Qian J, Ramirez AH. Comparison of family health history in surveys vs electronic health record data mapped to the observational medical outcomes partnership data model in the all of us research program. J Am Med Inform Assoc. 2021;28(4):695-703. Epub 2021/01/07. doi: 10.1093/jamia/ocaa315. PubMed PMID: 33404595; PMCID: PMC7973437.PubMed Link
33. Alkhatib N, Sweitzer NK, Lee CS, Erstad B, Slack M, Gharaibeh M, Karnes J, Klimecki W, Ramos K, Abraham I. Ex ante economic evaluation of arg389 genetically targeted treatment with bucindolol versus empirical treatment with carvedilol in nyha iii/iv heart failure. American Journal of Cardiovascular Drugs. 2021;21(2):205-17. doi: 10.1007/s40256-020-00425-x.PubMed Link
34. El Rouby N, Rodrigues Marcatto L, Claudio K, Camargo Tavares L, Steiner H, Botton MR, Lubitz SA, Fallon EN, Yee K, Kaye J, Scott SA, Karnes J, Caleb Junior de Lima Santos P, Duconge J, Cavallari LH. Multi-site investigation of genetic determinants of warfarin dose variability in latinos. Clin Transl Sci. 2021;14(1):268-76. Epub 2020/08/30. doi: 10.1111/cts.12854. PubMed PMID: 32860733; PMCID: PMC7877858.PubMed Link
35. Karnes JH, Schwantes-An TH, Kittles R, Desai AA. Reply to non and chang: Challenging the role of genetic ancestry in explaining racial/ethnic health disparities. Am J Respir Crit Care Med. 2021;203(3):398-9. Epub 2020/10/31. doi: 10.1164/rccm.202010-3846LE. PubMed PMID: 33125257; PMCID: PMC7874327.PubMed Link
36. Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M. Advancing precision medicine through the new pharmacogenomics global research network. Clin Pharmacol Ther. 2021;110(3):559-62. Epub 2021/07/29. doi: 10.1002/cpt.2340. PubMed PMID: 34318925.PubMed Link
37. Grace C, Larriva MM, Steiner HE, Marupuru S, Campbell PJ, Patterson H, Cropp CD, Quinn D, Klimecki W, Nix DE, Warholak T, Karnes JH. Efficacy of personal pharmacogenomic testing as an educational tool in the pharmacy curriculum: A nonblinded, randomized controlled trial. Clin Transl Sci. 2021. Epub 2021/08/26. doi: 10.1111/cts.13121. PubMed PMID: 34431601.PubMed Link
38. Hertz DL, Arwood MJ, Stocco G, Singh S, Karnes JH, Ramsey LB. Planning and conducting a pharmacogenetics association study. Clin Pharmacol Ther. 2021;110(3):688-701. Epub 2021/04/22. doi: 10.1002/cpt.2270. PubMed PMID: 33880756.PubMed Link
39. Karnes JH, Arora A, Feng J, Steiner HE, Sulieman L, Boerwinkle E, Clark C, Cicek M, Cohn E, Gebo K, Loperena-Cortes R, Ohno-Machado L, Mayo K, Mockrin S, Ramirez A, Schully S, Klimentidis YC. Racial, ethnic, and gender differences in obesity and body fat distribution: An all of us research program demonstration project. PLoS One. 2021;16(8):e0255583. Epub 2021/08/07. doi: 10.1371/journal.pone.0255583. PubMed PMID: 34358277; PMCID: PMC8345840.PubMed Link
40. Karnes JH, Rettie AE, Somogyi AA, Huddart R, Fohner AE, Formea CM, Ta Michael Lee M, Llerena A, Whirl-Carrillo M, Klein TE, Phillips EJ, Mintzer S, Gaedigk A, Caudle KE, Callaghan JT. Clinical pharmacogenetics implementation consortium (cpic) guideline for cyp2c9 and hla-b genotypes and phenytoin dosing: 2020 update. Clin Pharmacol Ther. 2021;109(2):302-9. Epub 2020/08/12. doi: 10.1002/cpt.2008. PubMed PMID: 32779747; PMCID: PMC7831382.PubMed Link
41. Toshner M, Church C, Harbaum L, Rhodes C, Villar Moreschi SS, Liley J, Jones R, Arora A, Batai K, Desai AA, Coghlan JG, Gibbs JSR, Gor D, Graf S, Harlow L, Hernandez-Sanchez J, Howard LS, Humbert M, Karnes J, Kiely DG, Kittles R, Knightbridge E, Lam B, Lutz KA, Nichols WC, Pauciulo MW, Pepke-Zaba J, Suntharalingam J, Soubrier F, Trembath RC, Schwantes-An TL, Wort SJ, Wilkins M, Gaine S, Morrell NW, Corris PA. Mendelian randomisation and experimental medicine approaches to il-6 as a drug target in pah. Eur Respir J. 2021. Epub 2021/10/01. doi: 10.1183/13993003.02463-2020. PubMed PMID: 34588193.PubMed Link
42. Alkhatib N, Sweitzer NK, Lee CS, Erstad B, Slack M, Gharaibeh M, Karnes J, Klimecki W, Ramos K, Abraham I. Ex ante economic evaluation of arg389 genetically targeted treatment with bucindolol versus empirical treatment with carvedilol in nyha iii/iv heart failure. Am J Cardiovasc Drugs. 2021;21(2):205-17. Epub 2020/07/28. doi: 10.1007/s40256-020-00425-x. PubMed PMID: 32710439.PubMed Link
43. Cronin RM, Halvorson AE, Springer C, Feng X, Sulieman L, Loperena-Cortes R, Mayo K, Carroll RJ, Chen Q, Ahmedani BK, Karnes J, Korf B, O’Donnell CJ, Qian J, Ramirez AH, All of Us Research Program Demonstration Projects Subcommittee obotAoURPI. Comparison of family health history in surveys vs electronic health record data mapped to the observational medical outcomes partnership data model in the all of us research program. Journal of the American Medical Informatics Association. 2021;28(4):695-703. doi: 10.1093/jamia/ocaa315.PubMed Link
44. Karnes JH, Wiener HW, Schwantes-An TH, Natarajan B, Sweatt AJ, Chaturvedi A, Arora A, Batai K, Nair V, Steiner HE, Giles JB, Yu J, Hosseini M, Pauciulo MW, Lutz KA, Coleman AW, Feldman J, Vanderpool R, Tang H, Garcia JGN, Yuan JX, Kittles R, de Jesus Perez V, Zamanian RT, Rischard F, Tiwari HK, Nichols WC, Benza RL, Desai AA. Genetic admixture and survival in diverse populations with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2020;201(11):1407-15. Epub 2020/01/10. doi: 10.1164/rccm.201907-1447OC. PubMed PMID: 31916850; PMCID: PMC7258627.PubMed Link
45. Ilori TO, Viera E, Wilson J, Moreno F, Menon U, Ehiri J, Peterson R, Vemulapalli T, StimsonRiahi SC, Rosales C, Calhoun E, Sokan A, Karnes JH, Reiman E, Ojo A, Theodorou A, Ojo T. Approach to high volume enrollment in clinical research: Experiences from an all of us research program site. Clin Transl Sci. 2020;13(4):685-92. Epub 2020/02/01. doi: 10.1111/cts.12759. PubMed PMID: 32004412; PMCID: PMC7359931.PubMed Link
46. Lynn H, Sun X, Casanova NG, Karnes JH, Camp S, Coletta D, Ellid N, Garcia JGN. Nicotinamide phosphoribosyl transferase (nampt) genotype-phenotype haplotype and elevated extracellular nampt levels predict mortality outcomes in acute respiratory distress syndrome (ards)2020:A4502-A. doi: 10.1164/ajrccm-conference.2020.201.1_MeetingAbstracts.A4502.PubMed Link
48. Patanwala AE, Norwood C, Steiner H, Morrison D, Li M, Walsh K, Martinez M, Baker SE, Snyder EM, Karnes JH. Psychological and genetic predictors of pain tolerance. Clin Transl Sci. 2019;12(2):189-95. Epub 2018/11/24. doi: 10.1111/cts.12605. PubMed PMID: 30468309; PMCID: PMC6440569.PubMed Link
49. Ramamoorthy A, Karnes JH, Finkel R, Blanchard R, Pacanowski M. Evolution of next generation therapeutics: Past, present, and future of precision medicines. Clin Transl Sci. 2019;12(6):560-3. Epub 2019/08/25. doi: 10.1111/cts.12675. PubMed PMID: 31444855; PMCID: PMC6853266.PubMed Link
50. Ramamoorthy A, Yee SW, Karnes J. Unveiling the genetic architecture of human disease for precision medicine. Clin Transl Sci. 2019;12(1):3-5. Epub 2018/11/27. doi: 10.1111/cts.12593. PubMed PMID: 30474919; PMCID: PMC6342243.PubMed Link
51. Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Tregouet DA, Prokopenko I, Kittles R, Graf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, Consortium UNBRD, Consortium UPCS, Consortium UPB. Genetic determinants of risk in pulmonary arterial hypertension: International genome-wide association studies and meta-analysis. Lancet Respir Med. 2019;7(3):227-38. Epub 2018/12/12. doi: 10.1016/S2213-2600(18)30409-0. PubMed PMID: 30527956; PMCID: PMC6391516.PubMed Link
52. Caudle KE, Gammal RS, Karnes JH, Afanasjeva J, Anderson KC, Barreto EF, Beavers C, Bhat S, Birrer KL, Chahine EB, Ensor CR, Flowers SA, Formea CM, George JM, Gosser RA, Hebert MF, Karaoui LR, Kolpek JH, Lee JC, Leung JG, Maldonado AQ, Minze MG, Pulk RA, Shelton CM, Sheridan M, Smith MA, Soefje S, Tellez-Corrales E, Walko CM, Cavallari LH. Prn opinion paper: Application of precision medicine across pharmacy specialty areas. Journal of the American College of Clinical Pharmacy. 2019;2(3):288-302. doi: 10.1002/jac5.1107.PubMed Link
53. Karnes JH, Miller MA, White KD, Konvinse KC, Pavlos RK, Redwood AJ, Peter JG, Lehloenya R, Mallal SA, Phillips EJ. Applications of immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions. Annu Rev Pharmacol Toxicol. 2019;59:463-86. Epub 2018/08/23. doi: 10.1146/annurev-pharmtox-010818-021818. PubMed PMID: 30134124; PMCID: PMC6409210.PubMed Link
54. Karnes JH. Pharmacogenetics to prevent heparin-induced thrombocytopenia: What do we know? Pharmacogenomics. 2018;19(18):1413-22. Epub 2018/11/07. doi: 10.2217/pgs-2018-0147. PubMed PMID: 30398086; PMCID: PMC6854440.PubMed Link
55. Lynn H, Sun X, Ayshiev D, Siegler JH, Rizzo AN, Karnes JH, Gonzales Garay M, Wang T, Casanova N, Camp SM, Ellis NA, Garcia JGN. Single nucleotide polymorphisms in the mylkp1 pseudogene are associated with increased colon cancer risk in african americans. PLoS One. 2018;13(8):e0200916. Epub 2018/08/31. doi: 10.1371/journal.pone.0200916. PubMed PMID: 30161129; PMCID: PMC6116948.PubMed Link
56. Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Verma SS, Karnes JH, Weiss ST, Wang TJ, Stein CM, Denny JC, Roden DM. A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers. Nat Commun. 2018;9(1):3522. Epub 2018/09/01. doi: 10.1038/s41467-018-05624-4. PubMed PMID: 30166544; PMCID: PMC6117367.PubMed Link
57. Bime C, Pouladi N, Sammani S, Batai K, Casanova N, Zhou T, Kempf CL, Sun X, Camp SM, Wang T, Kittles RA, Lussier YA, Jones TK, Reilly JP, Meyer NJ, Christie JD, Karnes JH, Gonzalez-Garay M, Christiani DC, Yates CR, Wurfel MM, Meduri GU, Garcia JGN. Genome-wide association study in african americans with acute respiratory distress syndrome identifies the selectin p ligand gene as a risk factor. Am J Respir Crit Care Med. 2018;197(11):1421-32. Epub 2018/02/10. doi: 10.1164/rccm.201705-0961OC. PubMed PMID: 29425463; PMCID: PMC6005557.PubMed Link
58. Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Zhao S, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with hla variants. Sci Transl Med. 2017;9(389). Epub 2017/05/12. doi: 10.1126/scitranslmed.aai8708. PubMed PMID: 28490672; PMCID: PMC5563969.PubMed Link
59. Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, Roden DM. Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Pharmacogenet Genomics. 2017;27(7):247-54. Epub 2017/05/26. doi: 10.1097/FPC.0000000000000284. PubMed PMID: 28542097; PMCID: PMC5502740.PubMed Link
60. Karnes JH, Shaffer CM, Bastarache L, Gaudieri S, Glazer AM, Steiner HE, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM. Comparison of hla allelic imputation programs. PLoS One. 2017;12(2):e0172444. Epub 2017/02/17. doi: 10.1371/journal.pone.0172444. PubMed PMID: 28207879; PMCID: PMC5312875.PubMed Link
61. Karnes JH, Shaffer CM, Cronin R, Bastarache L, Gaudieri S, James I, Pavlos R, Steiner HE, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM. Influence of human leukocyte antigen (hla) alleles and killer cell immunoglobulin-like receptors (kir) types on heparin-induced thrombocytopenia (hit). Pharmacotherapy. 2017;37(9):1164-71. Epub 2017/07/09. doi: 10.1002/phar.1983. PubMed PMID: 28688202; PMCID: PMC5600645.PubMed Link
62. Kaye JB, Schultz LE, Steiner HE, Kittles RA, Cavallari LH, Karnes JH. Warfarin pharmacogenomics in diverse populations. Pharmacotherapy. 2017;37(9):1150-63. Epub 2017/07/04. doi: 10.1002/phar.1982. PubMed PMID: 28672100; PMCID: PMC6913521.PubMed Link
63. Aljabri A, Huckleberry Y, Karnes JH, Gharaibeh M, Kutbi HI, Raz Y, Yun S, Abraham I, Erstad B. Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the united states. Blood. 2016;128(26):3043-51. Epub 2016/10/30. doi: 10.1182/blood-2016-07-728030. PubMed PMID: 27793877; PMCID: PMC6863170.PubMed Link
64. Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM. A genome-wide association study identifies variants in kcnip4 associated with ace inhibitor-induced cough. Pharmacogenomics J. 2016;16(3):231-7. Epub 2015/07/15. doi: 10.1038/tpj.2015.51. PubMed PMID: 26169577; PMCID: PMC4713364.PubMed Link
65. Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC. Identifying genetically driven clinical phenotypes using linear mixed models. Nat Commun. 2016;7:11433. Epub 2016/04/26. doi: 10.1038/ncomms11433. PubMed PMID: 27109359; PMCID: PMC4848547.PubMed Link
66. Sanders ML, Karnes JH, Denny JC, Roden DM, Ikizler TA, Birdwell KA. Clinical and genetic factors associated with cutaneous squamous cell carcinoma in kidney and heart transplant recipients. Transplant Direct. 2015;1(4). Epub 2015/07/07. doi: 10.1097/TXD.0000000000000521. PubMed PMID: 26146661; PMCID: PMC4486315.PubMed Link
67. Karnes JH, Cronin RM, Rollin J, Teumer A, Pouplard C, Shaffer CM, Blanquicett C, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Bakchoul T, Denny JC, Greinacher A, Gruel Y, Roden DM. A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record. Thromb Haemost. 2015;113(4):772-81. Epub 2014/12/17. doi: 10.1160/TH14-08-0670. PubMed PMID: 25503805; PMCID: PMC4433536.PubMed Link
68. Bowton E, Field JR, Wang S, Schildcrout JS, Van Driest SL, Delaney JT, Cowan J, Weeke P, Mosley JD, Wells QS, Karnes JH, Shaffer C, Peterson JF, Denny JC, Roden DM, Pulley JM. Biobanks and electronic medical records: Enabling cost-effective research. Sci Transl Med. 2014;6(234):234cm3. Epub 2014/05/03. doi: 10.1126/scitranslmed.3008604. PubMed PMID: 24786321; PMCID: PMC4226414.PubMed Link
69. Gong Y, McDonough CW, Beitelshees AL, Karnes JH, O'Connell JR, Turner ST, Chapman AB, Gums JG, Bailey KR, Boerwinkle E, Johnson JA, Cooper-DeHoff RM. Prox1 gene variant is associated with fasting glucose change after antihypertensive treatment. Pharmacotherapy. 2014;34(2):123-30. Epub 2013/10/15. doi: 10.1002/phar.1355. PubMed PMID: 24122840; PMCID: PMC3945213.PubMed Link
70. Gubbins PO, Micek ST, Badowski M, Cheng J, Gallagher J, Johnson SG, Karnes JH, Lyons K, Moore KG, Strnad K. Innovation in clinical pharmacy practice and opportunities for academic--practice partnership. Pharmacotherapy. 2014;34(5):e45-54. Epub 2014/05/31. doi: 10.1002/phar.1427. PubMed PMID: 24877189.PubMed Link
71. Karnes JH, Gong Y, Arwood MJ, Gums JG, Hall KL, Limacher MC, Johnson JA, Cooper-DeHoff RM. Alteration in fasting glucose after prolonged treatment with a thiazide diuretic. Diabetes Res Clin Pract. 2014;104(3):363-9. Epub 2014/05/06. doi: 10.1016/j.diabres.2014.04.004. PubMed PMID: 24794890; PMCID: PMC4074403.PubMed Link
72. Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Jr., Roden DM. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long qt interval syndrome. J Am Coll Cardiol. 2014;63(14):1430-7. Epub 2014/02/25. doi: 10.1016/j.jacc.2014.01.031. PubMed PMID: 24561134; PMCID: PMC4018823.PubMed Link
73. Karnes JH, Van Driest S, Bowton EA, Weeke PE, Mosley JD, Peterson JF, Denny JC, Roden DM. Using systems approaches to address challenges for clinical implementation of pharmacogenomics. Wiley Interdiscip Rev Syst Biol Med. 2014;6(2):125-35. Epub 2013/12/10. doi: 10.1002/wsbm.1255. PubMed PMID: 24319008; PMCID: PMC3944797.PubMed Link
74. Karnes JH, Gong Y, Pacanowski MA, McDonough CW, Arwood MJ, Langaee TY, Pepine CJ, Johnson JA, Cooper-Dehoff RM. Impact of tcf7l2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes. Pharmacogenet Genomics. 2013;23(12):697-705. Epub 2013/10/17. doi: 10.1097/FPC.0000000000000012. PubMed PMID: 24128935; PMCID: PMC3893755.PubMed Link
75. Karnes JH, Langaee TY, McDonough CW, Chang SW, Ramos M, Catlin JR, Jr., Casanova OE, Gong Y, Pepine CJ, Johnson JA, Cooper-Dehoff RM. Lack of association of the hmga1 ivs5-13insc variant with type 2 diabetes in an ethnically diverse hypertensive case control cohort. Journal of translational medicine. 2013;11:12. Epub 2013/01/11. doi: 10.1186/1479-5876-11-12. PubMed PMID: 23302499; PMCID: PMC3558451.PubMed Link
76. Karnes JH, McDonough CW, Gong Y, Vo TT, Langaee TY, Chapman AB, Gums JG, Beitelshees AL, Bailey KR, Del-Aguila JL, Boerwinkle EA, Pepine CJ, Turner ST, Johnson JA, Cooper-DeHoff RM. Association of kcnj1 variation with change in fasting glucose and new onset diabetes during hctz treatment. Pharmacogenomics J. 2013;13(5):430-6. Epub 2012/08/22. doi: 10.1038/tpj.2012.34. PubMed PMID: 22907731; PMCID: PMC3529742.PubMed Link
77. Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mechanistic phenotypes: An aggregative phenotyping strategy to identify disease mechanisms using gwas data. PLoS One. 2013;8(12):e81503. Epub 2013/12/19. doi: 10.1371/journal.pone.0081503. PubMed PMID: 24349080; PMCID: PMC3861317.PubMed Link
78. Karnes JH, Cooper-DeHoff RM. Antihypertensive medications: Benefits of blood pressure lowering and hazards of metabolic effects. Expert Rev Cardiovasc Ther. 2009;7(6):689-702. Epub 2009/06/10. doi: 10.1586/erc.09.31. PubMed PMID: 19505284; PMCID: PMC2799117.PubMed Link
79. Brunner M, Cooper-DeHoff RM, Gong Y, Karnes JH, Langaee TY, Pepine CJ, Johnson JA, Investigators I. Factors influencing blood pressure response to trandolapril add-on therapy in patients taking verapamil sr (from the international verapamil sr/trandolapril [invest] study). Am J Cardiol. 2007;99(11):1549-54. Epub 2007/05/29. doi: 10.1016/j.amjcard.2007.01.029. PubMed PMID: 17531579; PMCID: PMC2720593.PubMed Link
2. Baskir R, Lee M, McMaster S, Lee J, Blackburne-Proctor F, Azuine R, Mack N, Schully SD, Mendoza M, Sanchez J, Crosby Y, Zumba E, Hahn M, Aspaas N, Elmi A, Alerte S, Stewart E, Wilfong D, Doherty M, Farrell MM, Hébert MGB, Hood S, Thomas C, Murray D, Lee B, Karnes JH, Stark LA, Lewis MA, Uhrig JD, Bartlett L, Rico EG, Falcón A, Cohn E, Lunn MR, Obedin-Maliver J, Eder M, Cottler LB, Randall FT, Lemieux KT, Lemieux N, Lemieux N, Bradley L, Rodriguez M, Wilson M, Tepp R, Lunt C, Watson K. Research for All: Building a Diverse Researcher Community for the All of Us Research Program. JAMIA. 2024:ocae270.
3. Empey PE, Karnes JH, Johnson JA. Pharmacogenetics: Opportunities for the All of Us Research Program and Other Large Data Sets to Advance the Field. Annu Rev Pharmacol Toxicol. 2024 [In Press]
4. El Rouby N, Singh S, Stocco G, Theken K, Dickson A, Feng Q, Karnes J, Mosley J. Pharmacogenomics Polygenic Risk score: Ready or Not for Prime Time? Clin Transl Sci. 2024 [In Press]
5. Giles JB, Martinez KL, Steiner HE, Klein A, Ooi A, Pryor J, Sweitzer N, Fuchs D, Karnes JH. Association of Metal Cations with the Anti-PF4/Heparin Antibody Response in Heparin-Induced Thrombocytopenia. Cardiovasc Toxicol. 2024; 24(9):968-981. PMC10528503 PubMed Link
6. Tang H, Gupta A, Morrisroe S, Bao C, Schwantes-An TH, Gupta G, Liang S, Sun Y, Chu A, Luo A, Elangovan VR, Sangam S, Shi Y, Naidu S, Jheng JR, Ciftci-Yilmaz S, Warfel N, Hecker L, Mitra S, Coleman A, Lutz K, Pauciulo M, Lai YC, Javaheri A, Dharmakumar R, Wu WH, Flaherty D, Karnes J, Breuils-Bonnet S, Boucherat O, Bonnet S, Yuan J, Jacobson J, Duarte J, Nichols W, Garcia J, and Desai A. Deficiency of the Deubiquitinase, UCHL1, Attenuates Pulmonary Hypertension. Circulation. 2024 [In Press]
7. Jafari E, Blackman M, Karnes J, Van Driest S, Crawford D, Choi L, and McDonough C. Using Electronic Health Records for Clinical Pharmacology Research: Challenges and Considerations. Clin Transl Sci. 2024; 17(7):e13871. PMCID: PMC11213823 PubMed Link
8. Venner E, Patterson K, Kalra D, Wheeler M, Chen YJ, Kalla S, Yuan B, Karnes J, Walker K, Smith J, McGee S, Radhakrishnan A, Haddad A, Empey P, Wang Q, Lichtenstein L, Toledo D, Jarvik G, Musick A, Gibbs R, on behalf of the All of Us Research Program Investigators. The Frequency of Pathogenic Variation in the All of Us Cohort Reveals Ancestry-driven Disparities. Commun Biol. 2024; 19;7(1):174. PMCID: PMC10876563. PubMed Link
9. Tai YY, Yu Q, Tang Y, Sun W, Kelly N, Okawa S, Zhao J, Schwantes-An TH, Lacoux C, Torrino S, Al Aaraj Y, El Khoury W, Negi V, Liu M, Corey C, Belmonte F, Vargas S, Schwartz B, Bhat B, Chau B, Karnes JH, Satoh T, Barndt R, Wu H, Parikh V, Wang J, Zhang Y, McNamara D, Li G, Speyer G, Wang B, Shiva S, Kaufman BA, Kim S, Gomez D, Mari B, Cho M, Boueiz A, Pauciulo M, Southgate L, Trembath R, Sitbon O, Humbert M, Gräf S, Morrell N, Rhodes C, Wilkins M, Nouraie SM, Nichols W, Desai A, Bertero T, Chan SY. Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension. Sci Transl Med. 2024; 10;16(729):eadd2029. PMCID: PMC10947529 PubMed Link
10. Miller E, Sampson CUO, Desai AA, Karnes JH. Differential Drug Response in Pulmonary Arterial Hypertension: The Potential for Precision Medicine. Pulm Circ. 2023; 13(4):e12304. PMCID: PMC10621006. PubMed Link
11. Giles JB, Rollin J, Martinez KL, Selleng K, Thiele T, Pouplard C, Sheppard JI, Heddle NM, Phillips EJ, Roden DM, Gruel Y, Warkentin TE, Greinacher A, Karnes JH. Laboratory and Demographic Predictors of Functional Assay Positive Status in Suspected Heparin-Induced Thrombocytopenia: A Multicenter Retrospective Cohort Study. Thromb Res. 2023; 229:198-208. PMCID: PMC10528503. PubMed Link
12. Casanova NG, Chiang SM, Gonzalez-Garay ML, Batai K, Garman L, Montgomery CG, Ellis N, Kittles R, Bime C, Hsu A, Holland S, Lussier Y, Karnes J, Sweiss N, Maier LA, Koth L, Moller D, Kaminski N, Garcia JGN. Examination of eQTL Polymorphisms Associated with Increased Risk of Progressive Complicated Sarcoidosis in European and African Descent Subjects. Eur J Respir Med. 2023; 5(1):359-371. PMCID: PMC10883688. PubMed Link
13. Lynn H, Sun X, Casanova N, Bime C, Reyes-Hernon V, Lanham C, Oita R, Ramos N, Sun B, Coletta D, Camp S, Karnes JH, Ellis N, Garcia JGN. Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels and ARDS severity. Ther Adv Respir Dis. 17:17534666231181262. 2023 PMCID: PMC10363883. PubMed Link
14. Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu Q, Zagorski J, Morrisroe SA, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics. Am J Respir Crit Care Med. 2023; 207(8):1055-1069. PMCID: PMC10112457. PubMed Link
15. Feng J, Astiazaran-Symonds E, and Karnes JH. Visualization and Quantification of the Association Between Breast Cancer and Cholesterol in the All of Us Research Program. Cancer Inform. 2023; 22:11769351221144132. PMCID: PMC9841847. PubMed Link
16. Steiner HE, Carrion KC, Giles JB, Lima AR, Yee K, Sun X, Cavallari L, Perera M, Duconge J, Karnes JH. Local Ancestry-Informed Candidate Pathway Analysis of Warfarin Stable Dose in Latino Populations. Clin Pharmacol Ther. 2023; 113(3):680-691. PMCID: PMC9957812 PubMed Link
17. Steiner HE, Patterson HK, Giles JB, Karnes JH. Bringing Pharmacomicrobiomics to the Clinic Through Well-Designed Studies. Clin Transl Sci. 2022; 15(10):2303-2315. PMCID: PMC9579385PubMed Link
18. Giles JB, Steiner HE, Rollin J, Shaffer CM, Momozawa Y, Mushiroda T, Inai C, Selleng K, Thiele T, Pouplard C, Heddle NM, Kubo M, Miller EC, Martinez KL, Phillips EJ, Warkentin TE, Gruel Y, Greinacher A, Roden DM, Karnes JH. Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia. Blood Adv. 2022; 6(14):4137-4146. PMCID: PMC9327558. PubMed Link
19. Karnes JH, Rollin J, Giles JB, Martinez KL, Steiner HE, Shaffer CM, Momozawa Y, Inai C, Bombin A, Shi M, Mosley JD, Stanaway I, Selleng K, Thiele T, Mushiroda T, Pouplard C, Heddle NM, Kubo M, Phillips EJ, Warkentin TE, Gruel Y, Greinacher A, Roden DM. ABO O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia. Blood. 2022; 140(3):274-284. PMCID: PMC9305089. PubMed Link
20. Harbaum L, Rhodes CJ, Wharton J, Lawrie A, Karnes JH, Desai AA, Nichols WC, Humbert M, Montani D, Girerd B, Sitbon O, Boehm M, Novoyatleva T, Schermuly RT, Ghofrani HA, Toshner M, Kiely DG, Howard LS, Swietlik EM, Gräf S, Pietzner M, Morrell NW, Wilkins MR. Mining the plasma proteome for insights into the molecular pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2022; 205(12):1449-1460. PMCID: PMC9875902. PubMed Link
21. Karnes JH, Asempa T, Barreto J, Belcher RM, Bissell BD, Gamma RS, Kier KL, Lee CR, Liu L, McCune JS, Minhaj FS, Newsome AS, Ning J, Bookstaver PB. The Essential Research Curriculum for Doctor of Pharmacy Degree Programs: 2021 Update. J Am Coll Clin Pharm. 2022; 30(9):966. PMCID: PMC3061314. PubMed Link
22. Giles JB, Miller EC, Steiner HE, Karnes JH. Elucidation of Cellular Contributions to Heparin-Induced Thrombocytopenia Using Omic Approaches. Front Pharmacol. 2022; 12:812830. PMCID: PMC8814424 PubMed Link
23. Miller E, Norwood C, Giles JB, Huddart R, Karnes JH, Whirl-Carrillo M, Klein TE. PharmGKB Summary: Heparin Induced Thrombocytopenia (HIT) Pathway. Pharmacogenet Genomics. 2022; 32(3):117-124. PMCID: PMC8988468. PubMed Link
24. Steiner HE, Gee K, Giles J, Knight H, Hurwitz BL, Karnes JH. Role of the Gut Microbiome in Cardiovascular Drug Response: The Potential for Clinical Application. Pharmacotherapy 2021; 42(2):165-176. PMCID: PMC10321137. PubMed Link
25. Baxter SL, Saseendrakumar BR, Paul P, Kim J, Bonomi L, Kuo TT, Loperena R, Ratsimbazafy F, Boerwinkle E, Cicek M, Clark CR, Cohn E, Gebo K, Mayo K, Mockrin S, Schully SD, Ramirez A, Ohno-Machado L; All of Us Research Program Investigators (listed 42 out of 95 investigators). Predictive Analytics for Glaucoma Using Data From the All of Us Research Program. Am J Ophthalmol. 2021; 227:74-86. PMCID: PMC8184631. PubMed Link
26. Steiner HE, Giles JB, Patterson HK, Feng J, Rouby NE, Claudio K, Marcatto LR, Tavares LC, Galvez JM, Calderon-Ospina CA, Sun X, Hutz MH, Scott S, Cavallari LH, Fonseca DJ, Duconge J, Botton MR, Santos PCJL, Karnes J. Machine Learning for Prediction of Stable Warfarin Dose in US Latinos and Latin Americans. Front Pharmacol. 2021; 12:749786. PMCID: PMC8585774 PubMed Link
27. Karnes JH, Arora A, Feng J, Steiner HE, Sulieman L, Boerwinkle E, Clark C, Cicek M, Cohn E, Gebo K, Loperena-Cortes R, Ohno-Machado L, Mayo K, Mockrin S, Ramirez A, Schully S, Klimentidis YC, on behalf of the All of Us Research Program Investigators. Racial, Ethnic, and Gender Differences in Obesity and Body Fat Distribution: an All of Us Research Program Demonstration Project. Plos One. 2021; 16(8):e0255583. PMCID: PMC8345840 PubMed Link
28. Clark CR, Chandler PD, Zhou G, Noel N, Achille C, Mendez L, Karnes JH, Klimentidis YC, Jordan CD, Hiatt R, Ramirez AH, Loperena R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Schully S, Mockrin S, Gebo K, Karlson EW on behalf of the All of Us Research Program Investigators. Geographic Variation in Obesity at the State-Level in the All of Us Research Program. Prev Chronic Dis. 2021; 18:E104. PMCID: PMC8718125 PubMed Link
29. Grace C, Larriva MM, Steiner HE, Marupuru S, Campbell PJ, Patterson H, Cropp C, Quinn D, Klimecki W, Nix DE, Warholak T, Karnes JH. Efficacy of Personal Pharmacogenomic Testing as an Educational Tool in the Pharmacy Curriculum: A Non-Blinded, Randomized Controlled Trial. Clin Transl Sci. 2021; 14(6):2532-2543. PMCID: PMC8604226 PubMed Link
30. Toshner M, Church C, Harbaum L, Rhodes C, Villar S, Liley J, Jones R, Arora A, Batai K, Desai A, Coghlan J, Gibbs JS, Gor D, Gräf, S, Harlow L, Hernandez-Sanchez J, Howard L, Humbert M, Karnes J, Kiely D, Kittles R, Knightbridge E, Lam B, Lutz K, Nichols B, Pauciulo M, Pepke-Zaba J, Suntharalingam J, Soubrier F, Trembath R; Schwantes-An T-H, Wort S, Wilkins M, Gaine S, Morrell N, Corris P. Mendelian randomization and experimental medicine trial fail to support IL-6 as a drug target in pulmonary arterial hypertension. Eur Respir J. 2022; 59(3):2002463. PMCID: PMC8907935 PubMed Link
31. Deshpande P, Hertzman RJ, Palubinsky AM, Giles JB, Karnes JH, Gibson A, Phillips EJ. Immunopharmacogenomics: Mechanisms of hla-associated drug reactions. Clin Pharmacol Ther. 2021;110(3):607-15. Epub 2021/06/19. doi: 10.1002/cpt.2343. PubMed PMID: 34143437; PMCID: PMC8500648.PubMed Link
32. Cronin RM, Halvorson AE, Springer C, Feng X, Sulieman L, Loperena-Cortes R, Mayo K, Carroll RJ, Chen Q, Ahmedani BK, Karnes J, Korf B, O'Donnell CJ, Qian J, Ramirez AH. Comparison of family health history in surveys vs electronic health record data mapped to the observational medical outcomes partnership data model in the all of us research program. J Am Med Inform Assoc. 2021;28(4):695-703. Epub 2021/01/07. doi: 10.1093/jamia/ocaa315. PubMed PMID: 33404595; PMCID: PMC7973437.PubMed Link
33. Alkhatib N, Sweitzer NK, Lee CS, Erstad B, Slack M, Gharaibeh M, Karnes J, Klimecki W, Ramos K, Abraham I. Ex ante economic evaluation of arg389 genetically targeted treatment with bucindolol versus empirical treatment with carvedilol in nyha iii/iv heart failure. American Journal of Cardiovascular Drugs. 2021;21(2):205-17. doi: 10.1007/s40256-020-00425-x.PubMed Link
34. El Rouby N, Rodrigues Marcatto L, Claudio K, Camargo Tavares L, Steiner H, Botton MR, Lubitz SA, Fallon EN, Yee K, Kaye J, Scott SA, Karnes J, Caleb Junior de Lima Santos P, Duconge J, Cavallari LH. Multi-site investigation of genetic determinants of warfarin dose variability in latinos. Clin Transl Sci. 2021;14(1):268-76. Epub 2020/08/30. doi: 10.1111/cts.12854. PubMed PMID: 32860733; PMCID: PMC7877858.PubMed Link
35. Karnes JH, Schwantes-An TH, Kittles R, Desai AA. Reply to non and chang: Challenging the role of genetic ancestry in explaining racial/ethnic health disparities. Am J Respir Crit Care Med. 2021;203(3):398-9. Epub 2020/10/31. doi: 10.1164/rccm.202010-3846LE. PubMed PMID: 33125257; PMCID: PMC7874327.PubMed Link
36. Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M. Advancing precision medicine through the new pharmacogenomics global research network. Clin Pharmacol Ther. 2021;110(3):559-62. Epub 2021/07/29. doi: 10.1002/cpt.2340. PubMed PMID: 34318925.PubMed Link
37. Grace C, Larriva MM, Steiner HE, Marupuru S, Campbell PJ, Patterson H, Cropp CD, Quinn D, Klimecki W, Nix DE, Warholak T, Karnes JH. Efficacy of personal pharmacogenomic testing as an educational tool in the pharmacy curriculum: A nonblinded, randomized controlled trial. Clin Transl Sci. 2021. Epub 2021/08/26. doi: 10.1111/cts.13121. PubMed PMID: 34431601.PubMed Link
38. Hertz DL, Arwood MJ, Stocco G, Singh S, Karnes JH, Ramsey LB. Planning and conducting a pharmacogenetics association study. Clin Pharmacol Ther. 2021;110(3):688-701. Epub 2021/04/22. doi: 10.1002/cpt.2270. PubMed PMID: 33880756.PubMed Link
39. Karnes JH, Arora A, Feng J, Steiner HE, Sulieman L, Boerwinkle E, Clark C, Cicek M, Cohn E, Gebo K, Loperena-Cortes R, Ohno-Machado L, Mayo K, Mockrin S, Ramirez A, Schully S, Klimentidis YC. Racial, ethnic, and gender differences in obesity and body fat distribution: An all of us research program demonstration project. PLoS One. 2021;16(8):e0255583. Epub 2021/08/07. doi: 10.1371/journal.pone.0255583. PubMed PMID: 34358277; PMCID: PMC8345840.PubMed Link
40. Karnes JH, Rettie AE, Somogyi AA, Huddart R, Fohner AE, Formea CM, Ta Michael Lee M, Llerena A, Whirl-Carrillo M, Klein TE, Phillips EJ, Mintzer S, Gaedigk A, Caudle KE, Callaghan JT. Clinical pharmacogenetics implementation consortium (cpic) guideline for cyp2c9 and hla-b genotypes and phenytoin dosing: 2020 update. Clin Pharmacol Ther. 2021;109(2):302-9. Epub 2020/08/12. doi: 10.1002/cpt.2008. PubMed PMID: 32779747; PMCID: PMC7831382.PubMed Link
41. Toshner M, Church C, Harbaum L, Rhodes C, Villar Moreschi SS, Liley J, Jones R, Arora A, Batai K, Desai AA, Coghlan JG, Gibbs JSR, Gor D, Graf S, Harlow L, Hernandez-Sanchez J, Howard LS, Humbert M, Karnes J, Kiely DG, Kittles R, Knightbridge E, Lam B, Lutz KA, Nichols WC, Pauciulo MW, Pepke-Zaba J, Suntharalingam J, Soubrier F, Trembath RC, Schwantes-An TL, Wort SJ, Wilkins M, Gaine S, Morrell NW, Corris PA. Mendelian randomisation and experimental medicine approaches to il-6 as a drug target in pah. Eur Respir J. 2021. Epub 2021/10/01. doi: 10.1183/13993003.02463-2020. PubMed PMID: 34588193.PubMed Link
42. Alkhatib N, Sweitzer NK, Lee CS, Erstad B, Slack M, Gharaibeh M, Karnes J, Klimecki W, Ramos K, Abraham I. Ex ante economic evaluation of arg389 genetically targeted treatment with bucindolol versus empirical treatment with carvedilol in nyha iii/iv heart failure. Am J Cardiovasc Drugs. 2021;21(2):205-17. Epub 2020/07/28. doi: 10.1007/s40256-020-00425-x. PubMed PMID: 32710439.PubMed Link
43. Cronin RM, Halvorson AE, Springer C, Feng X, Sulieman L, Loperena-Cortes R, Mayo K, Carroll RJ, Chen Q, Ahmedani BK, Karnes J, Korf B, O’Donnell CJ, Qian J, Ramirez AH, All of Us Research Program Demonstration Projects Subcommittee obotAoURPI. Comparison of family health history in surveys vs electronic health record data mapped to the observational medical outcomes partnership data model in the all of us research program. Journal of the American Medical Informatics Association. 2021;28(4):695-703. doi: 10.1093/jamia/ocaa315.PubMed Link
44. Karnes JH, Wiener HW, Schwantes-An TH, Natarajan B, Sweatt AJ, Chaturvedi A, Arora A, Batai K, Nair V, Steiner HE, Giles JB, Yu J, Hosseini M, Pauciulo MW, Lutz KA, Coleman AW, Feldman J, Vanderpool R, Tang H, Garcia JGN, Yuan JX, Kittles R, de Jesus Perez V, Zamanian RT, Rischard F, Tiwari HK, Nichols WC, Benza RL, Desai AA. Genetic admixture and survival in diverse populations with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2020;201(11):1407-15. Epub 2020/01/10. doi: 10.1164/rccm.201907-1447OC. PubMed PMID: 31916850; PMCID: PMC7258627.PubMed Link
45. Ilori TO, Viera E, Wilson J, Moreno F, Menon U, Ehiri J, Peterson R, Vemulapalli T, StimsonRiahi SC, Rosales C, Calhoun E, Sokan A, Karnes JH, Reiman E, Ojo A, Theodorou A, Ojo T. Approach to high volume enrollment in clinical research: Experiences from an all of us research program site. Clin Transl Sci. 2020;13(4):685-92. Epub 2020/02/01. doi: 10.1111/cts.12759. PubMed PMID: 32004412; PMCID: PMC7359931.PubMed Link
46. Lynn H, Sun X, Casanova NG, Karnes JH, Camp S, Coletta D, Ellid N, Garcia JGN. Nicotinamide phosphoribosyl transferase (nampt) genotype-phenotype haplotype and elevated extracellular nampt levels predict mortality outcomes in acute respiratory distress syndrome (ards)2020:A4502-A. doi: 10.1164/ajrccm-conference.2020.201.1_MeetingAbstracts.A4502.PubMed Link
48. Patanwala AE, Norwood C, Steiner H, Morrison D, Li M, Walsh K, Martinez M, Baker SE, Snyder EM, Karnes JH. Psychological and genetic predictors of pain tolerance. Clin Transl Sci. 2019;12(2):189-95. Epub 2018/11/24. doi: 10.1111/cts.12605. PubMed PMID: 30468309; PMCID: PMC6440569.PubMed Link
49. Ramamoorthy A, Karnes JH, Finkel R, Blanchard R, Pacanowski M. Evolution of next generation therapeutics: Past, present, and future of precision medicines. Clin Transl Sci. 2019;12(6):560-3. Epub 2019/08/25. doi: 10.1111/cts.12675. PubMed PMID: 31444855; PMCID: PMC6853266.PubMed Link
50. Ramamoorthy A, Yee SW, Karnes J. Unveiling the genetic architecture of human disease for precision medicine. Clin Transl Sci. 2019;12(1):3-5. Epub 2018/11/27. doi: 10.1111/cts.12593. PubMed PMID: 30474919; PMCID: PMC6342243.PubMed Link
51. Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Tregouet DA, Prokopenko I, Kittles R, Graf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, Consortium UNBRD, Consortium UPCS, Consortium UPB. Genetic determinants of risk in pulmonary arterial hypertension: International genome-wide association studies and meta-analysis. Lancet Respir Med. 2019;7(3):227-38. Epub 2018/12/12. doi: 10.1016/S2213-2600(18)30409-0. PubMed PMID: 30527956; PMCID: PMC6391516.PubMed Link
52. Caudle KE, Gammal RS, Karnes JH, Afanasjeva J, Anderson KC, Barreto EF, Beavers C, Bhat S, Birrer KL, Chahine EB, Ensor CR, Flowers SA, Formea CM, George JM, Gosser RA, Hebert MF, Karaoui LR, Kolpek JH, Lee JC, Leung JG, Maldonado AQ, Minze MG, Pulk RA, Shelton CM, Sheridan M, Smith MA, Soefje S, Tellez-Corrales E, Walko CM, Cavallari LH. Prn opinion paper: Application of precision medicine across pharmacy specialty areas. Journal of the American College of Clinical Pharmacy. 2019;2(3):288-302. doi: 10.1002/jac5.1107.PubMed Link
53. Karnes JH, Miller MA, White KD, Konvinse KC, Pavlos RK, Redwood AJ, Peter JG, Lehloenya R, Mallal SA, Phillips EJ. Applications of immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions. Annu Rev Pharmacol Toxicol. 2019;59:463-86. Epub 2018/08/23. doi: 10.1146/annurev-pharmtox-010818-021818. PubMed PMID: 30134124; PMCID: PMC6409210.PubMed Link
54. Karnes JH. Pharmacogenetics to prevent heparin-induced thrombocytopenia: What do we know? Pharmacogenomics. 2018;19(18):1413-22. Epub 2018/11/07. doi: 10.2217/pgs-2018-0147. PubMed PMID: 30398086; PMCID: PMC6854440.PubMed Link
55. Lynn H, Sun X, Ayshiev D, Siegler JH, Rizzo AN, Karnes JH, Gonzales Garay M, Wang T, Casanova N, Camp SM, Ellis NA, Garcia JGN. Single nucleotide polymorphisms in the mylkp1 pseudogene are associated with increased colon cancer risk in african americans. PLoS One. 2018;13(8):e0200916. Epub 2018/08/31. doi: 10.1371/journal.pone.0200916. PubMed PMID: 30161129; PMCID: PMC6116948.PubMed Link
56. Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Verma SS, Karnes JH, Weiss ST, Wang TJ, Stein CM, Denny JC, Roden DM. A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers. Nat Commun. 2018;9(1):3522. Epub 2018/09/01. doi: 10.1038/s41467-018-05624-4. PubMed PMID: 30166544; PMCID: PMC6117367.PubMed Link
57. Bime C, Pouladi N, Sammani S, Batai K, Casanova N, Zhou T, Kempf CL, Sun X, Camp SM, Wang T, Kittles RA, Lussier YA, Jones TK, Reilly JP, Meyer NJ, Christie JD, Karnes JH, Gonzalez-Garay M, Christiani DC, Yates CR, Wurfel MM, Meduri GU, Garcia JGN. Genome-wide association study in african americans with acute respiratory distress syndrome identifies the selectin p ligand gene as a risk factor. Am J Respir Crit Care Med. 2018;197(11):1421-32. Epub 2018/02/10. doi: 10.1164/rccm.201705-0961OC. PubMed PMID: 29425463; PMCID: PMC6005557.PubMed Link
58. Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Zhao S, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with hla variants. Sci Transl Med. 2017;9(389). Epub 2017/05/12. doi: 10.1126/scitranslmed.aai8708. PubMed PMID: 28490672; PMCID: PMC5563969.PubMed Link
59. Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, Roden DM. Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Pharmacogenet Genomics. 2017;27(7):247-54. Epub 2017/05/26. doi: 10.1097/FPC.0000000000000284. PubMed PMID: 28542097; PMCID: PMC5502740.PubMed Link
60. Karnes JH, Shaffer CM, Bastarache L, Gaudieri S, Glazer AM, Steiner HE, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM. Comparison of hla allelic imputation programs. PLoS One. 2017;12(2):e0172444. Epub 2017/02/17. doi: 10.1371/journal.pone.0172444. PubMed PMID: 28207879; PMCID: PMC5312875.PubMed Link
61. Karnes JH, Shaffer CM, Cronin R, Bastarache L, Gaudieri S, James I, Pavlos R, Steiner HE, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM. Influence of human leukocyte antigen (hla) alleles and killer cell immunoglobulin-like receptors (kir) types on heparin-induced thrombocytopenia (hit). Pharmacotherapy. 2017;37(9):1164-71. Epub 2017/07/09. doi: 10.1002/phar.1983. PubMed PMID: 28688202; PMCID: PMC5600645.PubMed Link
62. Kaye JB, Schultz LE, Steiner HE, Kittles RA, Cavallari LH, Karnes JH. Warfarin pharmacogenomics in diverse populations. Pharmacotherapy. 2017;37(9):1150-63. Epub 2017/07/04. doi: 10.1002/phar.1982. PubMed PMID: 28672100; PMCID: PMC6913521.PubMed Link
63. Aljabri A, Huckleberry Y, Karnes JH, Gharaibeh M, Kutbi HI, Raz Y, Yun S, Abraham I, Erstad B. Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the united states. Blood. 2016;128(26):3043-51. Epub 2016/10/30. doi: 10.1182/blood-2016-07-728030. PubMed PMID: 27793877; PMCID: PMC6863170.PubMed Link
64. Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM. A genome-wide association study identifies variants in kcnip4 associated with ace inhibitor-induced cough. Pharmacogenomics J. 2016;16(3):231-7. Epub 2015/07/15. doi: 10.1038/tpj.2015.51. PubMed PMID: 26169577; PMCID: PMC4713364.PubMed Link
65. Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC. Identifying genetically driven clinical phenotypes using linear mixed models. Nat Commun. 2016;7:11433. Epub 2016/04/26. doi: 10.1038/ncomms11433. PubMed PMID: 27109359; PMCID: PMC4848547.PubMed Link
66. Sanders ML, Karnes JH, Denny JC, Roden DM, Ikizler TA, Birdwell KA. Clinical and genetic factors associated with cutaneous squamous cell carcinoma in kidney and heart transplant recipients. Transplant Direct. 2015;1(4). Epub 2015/07/07. doi: 10.1097/TXD.0000000000000521. PubMed PMID: 26146661; PMCID: PMC4486315.PubMed Link
67. Karnes JH, Cronin RM, Rollin J, Teumer A, Pouplard C, Shaffer CM, Blanquicett C, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Bakchoul T, Denny JC, Greinacher A, Gruel Y, Roden DM. A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record. Thromb Haemost. 2015;113(4):772-81. Epub 2014/12/17. doi: 10.1160/TH14-08-0670. PubMed PMID: 25503805; PMCID: PMC4433536.PubMed Link
68. Bowton E, Field JR, Wang S, Schildcrout JS, Van Driest SL, Delaney JT, Cowan J, Weeke P, Mosley JD, Wells QS, Karnes JH, Shaffer C, Peterson JF, Denny JC, Roden DM, Pulley JM. Biobanks and electronic medical records: Enabling cost-effective research. Sci Transl Med. 2014;6(234):234cm3. Epub 2014/05/03. doi: 10.1126/scitranslmed.3008604. PubMed PMID: 24786321; PMCID: PMC4226414.PubMed Link
69. Gong Y, McDonough CW, Beitelshees AL, Karnes JH, O'Connell JR, Turner ST, Chapman AB, Gums JG, Bailey KR, Boerwinkle E, Johnson JA, Cooper-DeHoff RM. Prox1 gene variant is associated with fasting glucose change after antihypertensive treatment. Pharmacotherapy. 2014;34(2):123-30. Epub 2013/10/15. doi: 10.1002/phar.1355. PubMed PMID: 24122840; PMCID: PMC3945213.PubMed Link
70. Gubbins PO, Micek ST, Badowski M, Cheng J, Gallagher J, Johnson SG, Karnes JH, Lyons K, Moore KG, Strnad K. Innovation in clinical pharmacy practice and opportunities for academic--practice partnership. Pharmacotherapy. 2014;34(5):e45-54. Epub 2014/05/31. doi: 10.1002/phar.1427. PubMed PMID: 24877189.PubMed Link
71. Karnes JH, Gong Y, Arwood MJ, Gums JG, Hall KL, Limacher MC, Johnson JA, Cooper-DeHoff RM. Alteration in fasting glucose after prolonged treatment with a thiazide diuretic. Diabetes Res Clin Pract. 2014;104(3):363-9. Epub 2014/05/06. doi: 10.1016/j.diabres.2014.04.004. PubMed PMID: 24794890; PMCID: PMC4074403.PubMed Link
72. Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Jr., Roden DM. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long qt interval syndrome. J Am Coll Cardiol. 2014;63(14):1430-7. Epub 2014/02/25. doi: 10.1016/j.jacc.2014.01.031. PubMed PMID: 24561134; PMCID: PMC4018823.PubMed Link
73. Karnes JH, Van Driest S, Bowton EA, Weeke PE, Mosley JD, Peterson JF, Denny JC, Roden DM. Using systems approaches to address challenges for clinical implementation of pharmacogenomics. Wiley Interdiscip Rev Syst Biol Med. 2014;6(2):125-35. Epub 2013/12/10. doi: 10.1002/wsbm.1255. PubMed PMID: 24319008; PMCID: PMC3944797.PubMed Link
74. Karnes JH, Gong Y, Pacanowski MA, McDonough CW, Arwood MJ, Langaee TY, Pepine CJ, Johnson JA, Cooper-Dehoff RM. Impact of tcf7l2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes. Pharmacogenet Genomics. 2013;23(12):697-705. Epub 2013/10/17. doi: 10.1097/FPC.0000000000000012. PubMed PMID: 24128935; PMCID: PMC3893755.PubMed Link
75. Karnes JH, Langaee TY, McDonough CW, Chang SW, Ramos M, Catlin JR, Jr., Casanova OE, Gong Y, Pepine CJ, Johnson JA, Cooper-Dehoff RM. Lack of association of the hmga1 ivs5-13insc variant with type 2 diabetes in an ethnically diverse hypertensive case control cohort. Journal of translational medicine. 2013;11:12. Epub 2013/01/11. doi: 10.1186/1479-5876-11-12. PubMed PMID: 23302499; PMCID: PMC3558451.PubMed Link
76. Karnes JH, McDonough CW, Gong Y, Vo TT, Langaee TY, Chapman AB, Gums JG, Beitelshees AL, Bailey KR, Del-Aguila JL, Boerwinkle EA, Pepine CJ, Turner ST, Johnson JA, Cooper-DeHoff RM. Association of kcnj1 variation with change in fasting glucose and new onset diabetes during hctz treatment. Pharmacogenomics J. 2013;13(5):430-6. Epub 2012/08/22. doi: 10.1038/tpj.2012.34. PubMed PMID: 22907731; PMCID: PMC3529742.PubMed Link
77. Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mechanistic phenotypes: An aggregative phenotyping strategy to identify disease mechanisms using gwas data. PLoS One. 2013;8(12):e81503. Epub 2013/12/19. doi: 10.1371/journal.pone.0081503. PubMed PMID: 24349080; PMCID: PMC3861317.PubMed Link
78. Karnes JH, Cooper-DeHoff RM. Antihypertensive medications: Benefits of blood pressure lowering and hazards of metabolic effects. Expert Rev Cardiovasc Ther. 2009;7(6):689-702. Epub 2009/06/10. doi: 10.1586/erc.09.31. PubMed PMID: 19505284; PMCID: PMC2799117.PubMed Link
79. Brunner M, Cooper-DeHoff RM, Gong Y, Karnes JH, Langaee TY, Pepine CJ, Johnson JA, Investigators I. Factors influencing blood pressure response to trandolapril add-on therapy in patients taking verapamil sr (from the international verapamil sr/trandolapril [invest] study). Am J Cardiol. 2007;99(11):1549-54. Epub 2007/05/29. doi: 10.1016/j.amjcard.2007.01.029. PubMed PMID: 17531579; PMCID: PMC2720593.PubMed Link
1. Steiner HE, Giles JB, Knight H, Fox K, Stanaway IB, Heise W, Karnes JH. Association of the ABO O Blood Group with Increased Warfarin Stable Dose. Pharmacogenomics Research Network Annual Meeting, October 2020.
2. Karnes JH, Weiner HW, Schwantes-An TH, Natarajan B, Chaturvedi A, Arora A, Batai K, Nair V, Steiner HE, Giles JB, Yu J, Hosseini M, Pauciulo MW, Lutz KA, Coleman AW, Feldman J, Vanderpool R, Tang H, Garcia JGN, Yuan JXJY, Rischard F, Kittles R, Tiwari HK, Nichols WC, Benza R, Desai AA. Genetic admixture and survival in diverse populations with pulmonary arterial hypertension (PAH). Circulation. 2019;140:A10124. American Heart Association Scientific Sessions, Philadelphia, PA, November 2019.
3. Karnes JH, Thayer T, Arora A, Batai K, Halladay S, Lutz K, Coleman A, Pauciulo M, Kittles R, Garcia JGN, Yuan JX, Geraci MW, West JD, Hemnes A, Stearman R, Nichols WC, Brittain A, Desai AA. Sorting Nexin 29 (SNX29) as a novel biomarker for Vasoresponsive Pulmonary Arterial Hypertension. American Thoracic Society Annual Meeting, Dallas, TX, May 2019.
4. El Rouby N, Marcatto L, Claudio K, Tavares L, Steiner H, Botton MR, Lubitz SA, Scott SA, Karnes J, Cavallari LH, Santos PCJL, Duconge J. Multi-Site Investigation of Pharmacogenetic Determinants of Warfarin Dose Variability in Latinos. American Society for Clinical Pharmacology and Therapeutics, Washington DC, March 2019. Clinical Pharmacology & Therapeutics 2019, 105(S1), S119 (OIII-02).
5. Karnes JH, Thayer T, Brittain E, Batai K, Arora A, Cyilmaz S, Ayon R, Lutz K, Walsworth A, Garcia JGN, Yuan JXJ, Pauciulo MW, Nichols WC, Kittles R, Desai AA. Genetic Determinants of Vasodilator Response in Pulmonary Arterial Hypertension. American Heart Association Scientific Sessions, Chicago, IL, November 2018. (Moderated Digital Poster Session)
6. Karnes JH, Natarajan B, Arora A, Batai K, Nair V, Hosseini M, Suryanarayana P, Lutz K, Walsworth A, Black SM, Garcia JGN, Paucilio MW, Kittles R, Yuan JXJ, Vanderpool R, Feldman J, Rischard F, Nichols WC, Desai AA. Genetic Admixture and Clinical Profiles in Minority Populations with Pulmonary Arterial Hypertension. Circulation. 2018;138:A14984. American Heart Association Scientific Sessions, Chicago, IL, November 2018.
7. Kaye JB, Steiner H, Wahl J, Sweitzer N, Karnes JH. Warfarin Pharmacogenomics in a Hispanic Population: A Candidate SNP Study. American College of Clinical Pharmacy, Seattle, WA, October 2018.
8. Steiner H, Larriva M, Campbell P, Nix DE, Quinn D, Klimecki W, and Karnes JH. Educational Benefit of Personal Pharmacogenomics Testing in the Pharmacy Curriculum. American College of Clinical Pharmacy, Seattle, WA, October 2018.
9. Karnes JH, Bastarache L, Shaffer CM, Mosley JD, Mallal S, Roden DM, Phillips EJ, Denny JC. Phenome-wide association study (PheWAS) for sex biases in human leukocyte antigen (HLA) associations. American Society of Human Genetics Annual Meeting, San Diego, CA, October 2018.
10. C.J. Rhodes K. Batai M. Bleda M. Haimel L. Southgate M. Germain M.W. Pauciulo C. Hadinnapola B. Girerd A. Arora J. Knight K. Hanscombe J. Karnes M. Kaakinen H.H. Gall A. Ulrich L. Harbaum J. Aman I. Cebola J. Ferrer L. Martin H. He A.E. Frost R.J. White K. Lutz A. Walsworth J. Wharton A. Lawrie M. Humbert F. Soubrier D. Tregouet I. Prokopenko R. Kittles S. Graef W.C. Nichols R. Trembath A.A. Desai N. Morrell M. Wilkins. Genetic Determinants of Risk and Survival in Pulmonary Arterial Hypertension. American Thoracic Society, San Diego, CA, May 2018.
11. Karnes JH, Batai K, Arora A, Kaye JB, Steiner HE, Nair V, Garcia JGN, Yuan JXJ, Pauciulo MW, Nichols WC, Kittles R, Desai AA. Genome-Wide Association Study of Vasodilator Response in Pulmonary Arterial Hypertension. Circulation. 2017; 136: A24015. American Heart Association Scientific Sessions (Late Breaking Basic Science Poster), Anaheim, CA, November 2017.
12. Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Linneman JG, Namjou B, Ritchie MD, Borthwick KM, Verma SS, Karnes JH, Wang TJ, Stein CM, Denny JC, Roden DM. Genetic predictors of biomarker levels derived from prospective epidemiologic cohorts applied to electronic health records to identify new biomarker-disease associations. American Society of Human Genetics Annual Meeting, Orlando, FL, October 2017.
13. Larriva MM, Campbell PJ, Nix DE, Quinn D, Klimecki W, Karnes JH. Efficacy of personal pharmacogenomic testing as an educational tool in the pharmacy curriculum. American College of Clinical Pharmacy Annual Meeting, Phoenix, AZ, October 2017.
14. Kaye JB, Schultz LE, Steiner HE, Kittles RA, Cavallari LH, Karnes JH. Performance of warfarin pharmacogenetic dosing algorithms in United States minority groups. American Indian Science and Engineering Society (AISES) National Conference, Minneapolis, MN, November 2016.
15. Aljabri A, Huckleberry YH, Karnes JH, Gharaibeh M, Kutbi H, Raz Y, Yun S, Abraham I, Erstad B. Cost-Effectiveness of Anticoagulants for the Management of Suspected Heparin-Induced Thrombocytopenia in the US. American Heart Association Scientific Sessions, New Orleans, LA, November 2016.
16. Karnes JH, Phillips EJ, Shaffer CM, Denny JC, Mosley JD, Roden DM. HLA-KIR Interactions in Heparin-Induced Thrombocytopenia. American College of Clinical Pharmacy Annual Meeting, Fort Lauderdale, FL, October 2016
17. Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC. A Clinical Catalogue of Phenotypes Associated with Variation in the MHC Locus. American Society of Human Genetics Annual Meeting, Vancouver, BC, CA, October 2016. (Selected as Reviewer’s Choice Abstract and featured in ASHG Poster Walk)
18. Bastarache L, Karnes JH, Shaffer CM, Gaudieri S, Glazer AM, Steiner H, Mosley JD, Mallal S, Phillips EJ, Denny JC, Roden DM. Comparison of HLA Allelic Imputation Programs. American Society of Human Genetics Annual Meeting, Vancouver, BC, CA, October 2016.
19. Kaye JB and Karnes JH. Literature review of performance of genotype-guided warfarin dosing algorithms in diverse ethnic groups. Association of American Indian Physicians (AAIP) 45th Annual Meeting, Oakland, CA, August 2016.
20. Hemler JA, Marston ES, Karnes JH, Glazer AM, Shaffer CM, Denny JC, Phillips EJ, Mallal SA, Kendall PL. A Study of Immunogenetic Associations with Peanut Allergy utilizing a Novel DNA Repository. American Academy of Allergy, Asthma & Immunology (AAAAI), Los Angeles, CA, March 2016.
21. Karnes JH, Denny JC, Cronin RM, Shaffer CM, Mosley JD, Mallal S, Phillips E, Roden DM. Association of HLA-DRB3*01:01 with Heparin-Induced Thrombocytopenia. American Heart Association Scientific Sessions, Orlando, FL, November 2015.
22. Karnes JH, Denny JC, Bowton EA, Shaffer CM, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Roden DM. Genome-wide association study of platelet factor 4/heparin antibody formation. October Clin Pharmacol Ther 2015;97(S1):S27-S28. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, New Orleans, LA, March 2015
23. Karnes JH, Denny JC, Cronin RM, Shaffer CM, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Roden DM. Influence of Exonic Variation on Heparin-Induced Thrombocytopenia. Circulation. 2014;130: A11449. American Heart Association Scientific Sessions, Chicago, IL, November 2014
24. Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei W, Teixeira PL, Bastarache L, Crawford DC, Manolio TA, Bottinger EP, McCarty CA, Jim Linneman, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Larson EB, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Ritchie MD, Denny JC, Roden DM. A genome-wide association study identified variants in KCNIP4 associated with ACE inhibitor induced cough. American Society of Human Genetics Annual Meeting, Boston, MA, October 2013.
25. Karnes JH, Mosley JD, Shaffer CM, Bowton EA, Delaney JT, Van Driest SL, Weeke PE, Wells QS, Denny JC, Roden DM. Genome-wide association study of fluoroquinolone-induced tendonitis. American College of Clinical Pharmacy Annual Meeting, Austin, TX, October 2014 (Selected as first runner-up among best fellow posters)
26. Sanders ML, Karnes JH, Denny JC, Roden DM, Ikizler TA, Birdwell KA. The Use of a DNA Biobank Linked to Electronic Medical Records to Determine Clinical and Genetic Predictors of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Recipients. World Transplant Congress, San Francisco, CA, July 2014. (Selected as a top poster in the “proteomics/genomics” category)
27. Weeke PE, Mosley JD, Hanna D, Shaffer CM, Delaney JT, Wells QS, Van Driest SL, Karnes JH, Ingram CR, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis E, Nickerson DA, George A, Roden DM. Exome Sequencing Implicates the Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome. American Heart Association Scientific Sessions, Dallas, TX, November 2013.
28. Wells QS, Mosley JD, Van Driest SL, Weeke P, Karnes JH, Shaffer CM, Bowton E, Denny JC and Roden DM. Genome-wide Association Identifies a Novel Locus for Anthracycline Cardiotoxicity. Circulation 2013; 128 (S22). American Heart Association Scientific Sessions, Dallas, TX, November 2013.
29. Sanders ML, Karnes JH, Denny JC, Roden DM, Ikizler TA, Birdwell KA. Clinical and genetic predictors of cutaneous squamous cell carcinoma in kidney transplant recipients. American Society of Nephrology Kidney Week 2013 Annual Meeting, Atlanta, GA, November 2013.
30. Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data. American Society of Human Genetics Annual Meeting, Boston, MA, October 2013.
31. Gong Y, Moore MJ, Karnes JH, McDonough CW, Wang Z, Langaee TY, Beitelshees AL, Turner ST, Chapman AB, Gums JG, Bailey KR, Boerwinkle E, Johnson JA, Cooper-DeHoff RM. Fasting glucose loci associated with glucose response to antihypertensives- results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. Clin Pharmacol Ther 2013;93(S1):S28. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Indianapolis, IN, March 2013.
32. Karnes JH, McDonough CW, Gong Y, Langaee TY, Pepine CJ, Johnson JA, Cooper-DeHoff RM. Alpha adducin-1 (ADD1) single nucleotide polymorphism associated with new onset diabetes risk with hydrochlorothiazide therapy in the International VErapamil SR Trandolapril GENEtic Substudy (INVEST-GENES). Clin Pharmacol Ther 2012;91(S1):S21. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, National Harbor, MD, March 2012.
33. Karnes JH, Vo TT, Gong Y, Langaee TY, Beitelshees AL, Turner ST, Chapman AB, Gums JG, Bailey K, Boerwinkle E, Pepine CJ, Johnson JA, Cooper-DeHoff RM. KCNJ1 SNPs are associated with increased fasting glucose and risk of new onset diabetes during HCTZ therapy. Clin Pharmacol Ther 2011;89(S1):S46. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Dallas, TX, March 2011.
34. Karnes JH, George AM, Gong Y, Langaee TY, Stauffer LA, Burkley BM, Pepine CJ, Johnson JA, Cooper-DeHoff RM. New-Onset Diabetes Risk Associated with Antihypertensive Therapy in Hypertensive Coronary Artery Disease Patients is Modified by a Single Nucleotide Polymorphism (SNP) in the L-Type Calcium Channel (LTCC) Alpha 1C Subunit Gene (CACNA1C). Clin Pharmacol Ther 2010;87(S1):S45. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Atlanta, GA, March 2010. 35. Karnes JH, Brunner M, Gong Y, Langaee TY, Cooper-DeHoff RM, Pepine CJ, Johnson JA. Lack of Assocation of the Angiotensin II Type I Receptor (AGTR1) 1166A>C Polymorphism with cardiovascular and cerebrovascular Outcomes in a Subgroup of Patients of the International Verapamil SR/Trandolapril Study (INVEST). Clin Pharmacol Ther 2006;79(2):P43. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Baltimore, MD, March 2006.
36. Brunner M, Karnes JH, Gong Y, Langaee TY, Cooper-DeHoff RM, Pepine CJ, Johnson JA. Association of angiotensin II type I receptor (AGTR1) 1166A>C polymorphism with blood pressure response to ace inhibitor in a subgroup of patients of the International Verapamil CR/trandolapril Study (INVEST). Clin Pharmacol Ther 2006;79(2):P14. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Baltimore, MD, March 2006.
2. Karnes JH, Weiner HW, Schwantes-An TH, Natarajan B, Chaturvedi A, Arora A, Batai K, Nair V, Steiner HE, Giles JB, Yu J, Hosseini M, Pauciulo MW, Lutz KA, Coleman AW, Feldman J, Vanderpool R, Tang H, Garcia JGN, Yuan JXJY, Rischard F, Kittles R, Tiwari HK, Nichols WC, Benza R, Desai AA. Genetic admixture and survival in diverse populations with pulmonary arterial hypertension (PAH). Circulation. 2019;140:A10124. American Heart Association Scientific Sessions, Philadelphia, PA, November 2019.
3. Karnes JH, Thayer T, Arora A, Batai K, Halladay S, Lutz K, Coleman A, Pauciulo M, Kittles R, Garcia JGN, Yuan JX, Geraci MW, West JD, Hemnes A, Stearman R, Nichols WC, Brittain A, Desai AA. Sorting Nexin 29 (SNX29) as a novel biomarker for Vasoresponsive Pulmonary Arterial Hypertension. American Thoracic Society Annual Meeting, Dallas, TX, May 2019.
4. El Rouby N, Marcatto L, Claudio K, Tavares L, Steiner H, Botton MR, Lubitz SA, Scott SA, Karnes J, Cavallari LH, Santos PCJL, Duconge J. Multi-Site Investigation of Pharmacogenetic Determinants of Warfarin Dose Variability in Latinos. American Society for Clinical Pharmacology and Therapeutics, Washington DC, March 2019. Clinical Pharmacology & Therapeutics 2019, 105(S1), S119 (OIII-02).
5. Karnes JH, Thayer T, Brittain E, Batai K, Arora A, Cyilmaz S, Ayon R, Lutz K, Walsworth A, Garcia JGN, Yuan JXJ, Pauciulo MW, Nichols WC, Kittles R, Desai AA. Genetic Determinants of Vasodilator Response in Pulmonary Arterial Hypertension. American Heart Association Scientific Sessions, Chicago, IL, November 2018. (Moderated Digital Poster Session)
6. Karnes JH, Natarajan B, Arora A, Batai K, Nair V, Hosseini M, Suryanarayana P, Lutz K, Walsworth A, Black SM, Garcia JGN, Paucilio MW, Kittles R, Yuan JXJ, Vanderpool R, Feldman J, Rischard F, Nichols WC, Desai AA. Genetic Admixture and Clinical Profiles in Minority Populations with Pulmonary Arterial Hypertension. Circulation. 2018;138:A14984. American Heart Association Scientific Sessions, Chicago, IL, November 2018.
7. Kaye JB, Steiner H, Wahl J, Sweitzer N, Karnes JH. Warfarin Pharmacogenomics in a Hispanic Population: A Candidate SNP Study. American College of Clinical Pharmacy, Seattle, WA, October 2018.
8. Steiner H, Larriva M, Campbell P, Nix DE, Quinn D, Klimecki W, and Karnes JH. Educational Benefit of Personal Pharmacogenomics Testing in the Pharmacy Curriculum. American College of Clinical Pharmacy, Seattle, WA, October 2018.
9. Karnes JH, Bastarache L, Shaffer CM, Mosley JD, Mallal S, Roden DM, Phillips EJ, Denny JC. Phenome-wide association study (PheWAS) for sex biases in human leukocyte antigen (HLA) associations. American Society of Human Genetics Annual Meeting, San Diego, CA, October 2018.
10. C.J. Rhodes K. Batai M. Bleda M. Haimel L. Southgate M. Germain M.W. Pauciulo C. Hadinnapola B. Girerd A. Arora J. Knight K. Hanscombe J. Karnes M. Kaakinen H.H. Gall A. Ulrich L. Harbaum J. Aman I. Cebola J. Ferrer L. Martin H. He A.E. Frost R.J. White K. Lutz A. Walsworth J. Wharton A. Lawrie M. Humbert F. Soubrier D. Tregouet I. Prokopenko R. Kittles S. Graef W.C. Nichols R. Trembath A.A. Desai N. Morrell M. Wilkins. Genetic Determinants of Risk and Survival in Pulmonary Arterial Hypertension. American Thoracic Society, San Diego, CA, May 2018.
11. Karnes JH, Batai K, Arora A, Kaye JB, Steiner HE, Nair V, Garcia JGN, Yuan JXJ, Pauciulo MW, Nichols WC, Kittles R, Desai AA. Genome-Wide Association Study of Vasodilator Response in Pulmonary Arterial Hypertension. Circulation. 2017; 136: A24015. American Heart Association Scientific Sessions (Late Breaking Basic Science Poster), Anaheim, CA, November 2017.
12. Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Linneman JG, Namjou B, Ritchie MD, Borthwick KM, Verma SS, Karnes JH, Wang TJ, Stein CM, Denny JC, Roden DM. Genetic predictors of biomarker levels derived from prospective epidemiologic cohorts applied to electronic health records to identify new biomarker-disease associations. American Society of Human Genetics Annual Meeting, Orlando, FL, October 2017.
13. Larriva MM, Campbell PJ, Nix DE, Quinn D, Klimecki W, Karnes JH. Efficacy of personal pharmacogenomic testing as an educational tool in the pharmacy curriculum. American College of Clinical Pharmacy Annual Meeting, Phoenix, AZ, October 2017.
14. Kaye JB, Schultz LE, Steiner HE, Kittles RA, Cavallari LH, Karnes JH. Performance of warfarin pharmacogenetic dosing algorithms in United States minority groups. American Indian Science and Engineering Society (AISES) National Conference, Minneapolis, MN, November 2016.
15. Aljabri A, Huckleberry YH, Karnes JH, Gharaibeh M, Kutbi H, Raz Y, Yun S, Abraham I, Erstad B. Cost-Effectiveness of Anticoagulants for the Management of Suspected Heparin-Induced Thrombocytopenia in the US. American Heart Association Scientific Sessions, New Orleans, LA, November 2016.
16. Karnes JH, Phillips EJ, Shaffer CM, Denny JC, Mosley JD, Roden DM. HLA-KIR Interactions in Heparin-Induced Thrombocytopenia. American College of Clinical Pharmacy Annual Meeting, Fort Lauderdale, FL, October 2016
17. Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC. A Clinical Catalogue of Phenotypes Associated with Variation in the MHC Locus. American Society of Human Genetics Annual Meeting, Vancouver, BC, CA, October 2016. (Selected as Reviewer’s Choice Abstract and featured in ASHG Poster Walk)
18. Bastarache L, Karnes JH, Shaffer CM, Gaudieri S, Glazer AM, Steiner H, Mosley JD, Mallal S, Phillips EJ, Denny JC, Roden DM. Comparison of HLA Allelic Imputation Programs. American Society of Human Genetics Annual Meeting, Vancouver, BC, CA, October 2016.
19. Kaye JB and Karnes JH. Literature review of performance of genotype-guided warfarin dosing algorithms in diverse ethnic groups. Association of American Indian Physicians (AAIP) 45th Annual Meeting, Oakland, CA, August 2016.
20. Hemler JA, Marston ES, Karnes JH, Glazer AM, Shaffer CM, Denny JC, Phillips EJ, Mallal SA, Kendall PL. A Study of Immunogenetic Associations with Peanut Allergy utilizing a Novel DNA Repository. American Academy of Allergy, Asthma & Immunology (AAAAI), Los Angeles, CA, March 2016.
21. Karnes JH, Denny JC, Cronin RM, Shaffer CM, Mosley JD, Mallal S, Phillips E, Roden DM. Association of HLA-DRB3*01:01 with Heparin-Induced Thrombocytopenia. American Heart Association Scientific Sessions, Orlando, FL, November 2015.
22. Karnes JH, Denny JC, Bowton EA, Shaffer CM, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Roden DM. Genome-wide association study of platelet factor 4/heparin antibody formation. October Clin Pharmacol Ther 2015;97(S1):S27-S28. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, New Orleans, LA, March 2015
23. Karnes JH, Denny JC, Cronin RM, Shaffer CM, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Roden DM. Influence of Exonic Variation on Heparin-Induced Thrombocytopenia. Circulation. 2014;130: A11449. American Heart Association Scientific Sessions, Chicago, IL, November 2014
24. Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei W, Teixeira PL, Bastarache L, Crawford DC, Manolio TA, Bottinger EP, McCarty CA, Jim Linneman, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Larson EB, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Ritchie MD, Denny JC, Roden DM. A genome-wide association study identified variants in KCNIP4 associated with ACE inhibitor induced cough. American Society of Human Genetics Annual Meeting, Boston, MA, October 2013.
25. Karnes JH, Mosley JD, Shaffer CM, Bowton EA, Delaney JT, Van Driest SL, Weeke PE, Wells QS, Denny JC, Roden DM. Genome-wide association study of fluoroquinolone-induced tendonitis. American College of Clinical Pharmacy Annual Meeting, Austin, TX, October 2014 (Selected as first runner-up among best fellow posters)
26. Sanders ML, Karnes JH, Denny JC, Roden DM, Ikizler TA, Birdwell KA. The Use of a DNA Biobank Linked to Electronic Medical Records to Determine Clinical and Genetic Predictors of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Recipients. World Transplant Congress, San Francisco, CA, July 2014. (Selected as a top poster in the “proteomics/genomics” category)
27. Weeke PE, Mosley JD, Hanna D, Shaffer CM, Delaney JT, Wells QS, Van Driest SL, Karnes JH, Ingram CR, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis E, Nickerson DA, George A, Roden DM. Exome Sequencing Implicates the Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome. American Heart Association Scientific Sessions, Dallas, TX, November 2013.
28. Wells QS, Mosley JD, Van Driest SL, Weeke P, Karnes JH, Shaffer CM, Bowton E, Denny JC and Roden DM. Genome-wide Association Identifies a Novel Locus for Anthracycline Cardiotoxicity. Circulation 2013; 128 (S22). American Heart Association Scientific Sessions, Dallas, TX, November 2013.
29. Sanders ML, Karnes JH, Denny JC, Roden DM, Ikizler TA, Birdwell KA. Clinical and genetic predictors of cutaneous squamous cell carcinoma in kidney transplant recipients. American Society of Nephrology Kidney Week 2013 Annual Meeting, Atlanta, GA, November 2013.
30. Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data. American Society of Human Genetics Annual Meeting, Boston, MA, October 2013.
31. Gong Y, Moore MJ, Karnes JH, McDonough CW, Wang Z, Langaee TY, Beitelshees AL, Turner ST, Chapman AB, Gums JG, Bailey KR, Boerwinkle E, Johnson JA, Cooper-DeHoff RM. Fasting glucose loci associated with glucose response to antihypertensives- results from the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. Clin Pharmacol Ther 2013;93(S1):S28. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Indianapolis, IN, March 2013.
32. Karnes JH, McDonough CW, Gong Y, Langaee TY, Pepine CJ, Johnson JA, Cooper-DeHoff RM. Alpha adducin-1 (ADD1) single nucleotide polymorphism associated with new onset diabetes risk with hydrochlorothiazide therapy in the International VErapamil SR Trandolapril GENEtic Substudy (INVEST-GENES). Clin Pharmacol Ther 2012;91(S1):S21. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, National Harbor, MD, March 2012.
33. Karnes JH, Vo TT, Gong Y, Langaee TY, Beitelshees AL, Turner ST, Chapman AB, Gums JG, Bailey K, Boerwinkle E, Pepine CJ, Johnson JA, Cooper-DeHoff RM. KCNJ1 SNPs are associated with increased fasting glucose and risk of new onset diabetes during HCTZ therapy. Clin Pharmacol Ther 2011;89(S1):S46. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Dallas, TX, March 2011.
34. Karnes JH, George AM, Gong Y, Langaee TY, Stauffer LA, Burkley BM, Pepine CJ, Johnson JA, Cooper-DeHoff RM. New-Onset Diabetes Risk Associated with Antihypertensive Therapy in Hypertensive Coronary Artery Disease Patients is Modified by a Single Nucleotide Polymorphism (SNP) in the L-Type Calcium Channel (LTCC) Alpha 1C Subunit Gene (CACNA1C). Clin Pharmacol Ther 2010;87(S1):S45. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Atlanta, GA, March 2010. 35. Karnes JH, Brunner M, Gong Y, Langaee TY, Cooper-DeHoff RM, Pepine CJ, Johnson JA. Lack of Assocation of the Angiotensin II Type I Receptor (AGTR1) 1166A>C Polymorphism with cardiovascular and cerebrovascular Outcomes in a Subgroup of Patients of the International Verapamil SR/Trandolapril Study (INVEST). Clin Pharmacol Ther 2006;79(2):P43. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Baltimore, MD, March 2006.
36. Brunner M, Karnes JH, Gong Y, Langaee TY, Cooper-DeHoff RM, Pepine CJ, Johnson JA. Association of angiotensin II type I receptor (AGTR1) 1166A>C polymorphism with blood pressure response to ace inhibitor in a subgroup of patients of the International Verapamil CR/trandolapril Study (INVEST). Clin Pharmacol Ther 2006;79(2):P14. American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Baltimore, MD, March 2006.
Karnes JH and Ramsey LB. Chapter 7: Pharmacogenetics and Molecular Testing. 7th edition of Basic Skills in Interpreting Laboratory Data. Eds: Edwards CJ, Erstad BL. American Society of Health-System Pharmacists, Bethesda, MD: 2021 [In Press]
Pavlos R, Karnes JH, Trubiano J, Peter J, Phillips E. Pharmacogenomics of Drug Allergy. Drug Allergy Testing, 1st Edition. Eds: Khan D, Banerji A. Elsevier, St Louis, Missouri. 2018, pp. 39-51.
Pavlos R, Karnes JH, Trubiano J, Peter J, Phillips E. Pharmacogenomics of Drug Allergy. Drug Allergy Testing, 1st Edition. Eds: Khan D, Banerji A. Elsevier, St Louis, Missouri. 2018, pp. 39-51.
Karnes JH, Schwantes-An T, Desai AA. Response to “Reply to: Challenging the role of genetic ancestry in explaining racial/ethnic health disparities”. Am J Respir Crit Care Med. 2020. PMID: 33125257 [In Press]
Karnes JH, Erstad B, Aljabri A, Huckleberry Y, Gharaibeh M, Kutbi HI, Raz Y, Yun S and Abraham I. Medical Management of Heparin-Induced Thrombocytopenia: Pharmacoeconomic Considerations. Blood e-letter (19 June, 2017)
Karnes JH, Erstad B, Aljabri A, Huckleberry Y, Gharaibeh M, Kutbi HI, Raz Y, Yun S and Abraham I. Medical Management of Heparin-Induced Thrombocytopenia: Pharmacoeconomic Considerations. Blood e-letter (19 June, 2017)
Publication Highlights
2021
Karnes JH, Schwantes-An TH, Kittles R, Desai AA. Reply to Non and Chang: Challenging the Role of Genetic Ancestry in Explaining Racial/Ethnic Health Disparities. Am J Respir Crit Care Med. 2021 Feb 1;203(3):398-399. doi: 10.1164/rccm.202010-3846LE. PMID: 33125257; PMCID: PMC7874327.
PubMed Article
2020
El Rouby N, Rodrigues Marcatto L, Claudio K, Camargo Tavares L, Steiner H, Botton MR, Lubitz SA, Fallon EN, Yee K, Kaye J, Scott SA, Karnes J, Caleb Junior de Lima Santos P, Duconge J, Cavallari LH. Multi-site Investigation of Genetic Determinants of Warfarin Dose Variability in Latinos. Clin Transl Sci. 2020 Aug 29. doi: 10.1111/cts.12854. Epub ahead of print. PMID: 32860733.
PubMed Article
Ilori, T.O., Viera, E., Wilson, J., Moreno, F., Menon, U., Ehiri, J., Peterson, R., Vemulapalli, T., StimsonRiahi, S.C., Rosales, C., Calhoun, E., Sokan, A., Karnes, J.H., Reiman, E., Ojo, A., Theodorou, A. and Ojo, T. (2020), Approach to high volume enrollment in clinical research: Experiences from an allofus® research program site. Clin Transl Sci. Accepted Author Manuscript. doi:10.1111/cts.12759
PubMed Article
Karnes JH, Weiner HW, Schwantes-An T, Natarajan B, Sweatt AJ, Chaturvedi A, Arora A, Batai K, Nair V, Steiner HE, Giles JB, Yu J, Hosseini M, Pauciulo MW, Lutz KA, Coleman AW, Feldman J, Vanderpool R, Tang H, Garcia JGN, Yuan JXJ, Kittles R, Perez VDJ, Zamanian RT, Rischard F, Tiwari HK, Nichols WC, Benza RL, Desai AA. Genetic admixture and survival in diverse populations with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2020 [In Press]
PubMed Article
2019
Patanwala, A. E., C. Norwood, H. Steiner, D. Morrison, M. Li, K. Walsh, M. Martinez, S. E. Baker, E. M. Snyder, and J. H. Karnes, "Psychological and Genetic Predictors of Pain Tolerance.", Clin Transl Sci, vol. 12, issue 2, pp. 189-195, 2019 Mar. PMCID: PMC6440569
PubMed Article
Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen K, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett CF, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala MM, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley JB, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, Ross RVM, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins IM, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AT, Thenappan T, Torres F, Toshner MR, Treacy CM, Noordegraaf AV, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR. Genetic determinants of risk in pulmonary arterial hypertension: international case-control studies and meta-analysis. Lancet Respir Med 2019; 7(3):227-238
PubMed Article
Karnes, J. H., M. A. Miller, K. D. White, K. C. Konvinse, R. K. Pavlos, A. J. Redwood, J. G. Peter, R. Lehloenya, S. A. Mallal, and E. J. Phillips, "Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions.", Annu Rev Pharmacol Toxicol, vol. 59, pp. 463-486, 2019 Jan 06. PMCID: PMC6409210 PMID: 30134124
PubMed Article
2018
Karnes, J. H., "Pharmacogenetics to prevent heparin-induced thrombocytopenia: what do we know?", Pharmacogenomics, vol. 19, issue 18, pp. 1413-1422, 2018 12.
PubMed Article
2017
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