RESEARCH FUNDING
CURRENT
OT2OD036485 (PIs: Karnes, Moreno, Solomon, Subbian) 09/15/2023-08/31/2024NIH/Office of the Director
Precision Medicine for All of Us Researchers Collective (Medicina de Precision: Colectivo de Investigadores Salud para Todos)
R21HL172036 (PIs: Karnes, Wheeler) 09/10/2023-07/31/2025
NIH/National Heart, Lung, and Blood Institute
Discovery of Immunogenomic Associations with Disease and Differential Risk Across Diverse Populations
In this project, we perform systematic investigation of the association of human leukocyte antigen (HLA) alleles with disease, using a two-pronged approach based on the phenome-wide association study (PheWAS) in the All of Us Research Program, a large, diverse DNA biobank coupled to electronic health records.
R01HD111125 (PI: Erickson) 08/01/2023-05/31/2028
NIH/National Heart, Lung, and Blood Institute
Oxytocin sensitivity and postpartum hemorrhage: testing genetic and epigenetic biomarkers for improving maternal morbidity
In this project, we aim to examine genetic and epigenetic variation in OXTR in relationship to clinical outcomes linked to poor uterine contractility and postpartum hemorrhage using banked and prospectively collected data in addition to measuring dose-response oxytocin stimulated uterine contractility in vitro using myography.
Role: Co-I
R01 HL156993 (PI: Karnes) 07/01/2022-06/30/2026
NIH/National Heart, Lung, and Blood Institute
ABO and Immunogenetic Variation in the Pathogenesis of Heparin-Induced Thrombocytopenia
The goals of this work are to determine the role of ABO variation in heparin-induced thrombocytopenia, determine the influence of genomic variation on platelet factor 4/heparin antibody production, and to identify intrinsic immune cell involvement in HIT using a single cell-RNA-TCR-CITE-seq approach.
Role: PI
R01 HL158686 (PI: Karnes) 08/01/2021-05/31/2026
NIH/National Heart, Lung, and Blood Institute
Leveraging the Microbiome, Local Admixture, and Machine Learning to Optimize Anticoagulant Pharmacogenomics in Medically Underserved Patients
The goal of this work is to provide a framework for investigation of the microbiome, local ancestry, and machine learning to identify new sources of variability in warfarin dose, improve the safety and efficacy of warfarin treatment, and reduce disparities in pharmacogenomic research for medically underserved patients.
Role: PI
1OT2OD026549 (PIs: Kron, Reiman, Theodorou, Moreno, Peterson) 04/01/18–03/31/24
NIH/Office of the Director
University of Arizona - Banner Health All of Us Research Program
Role: Co-I
Administrative Supplement to Advance Precision Medicine Using the All of Us Research Program’s Data: R01 HL158686 (PI: Karnes)
08/12/2022-07/31/2023
NIH/National Heart, Lung, and Blood Institute
Role: PI
K01HL143137 (PI: Karnes)
04/01/19–06/30/22 (award returned early due to multiple R01s)
NIH/National Heart, Lung, and Blood Institute
Genomic and Transcriptomic Influences on Heparin-Induced Thrombocytopenia
The primary goal of this career development award is to determine the influence of genomic and transcriptomic variation on the development of heparin-induced thrombocytopenia (HIT).
Role: PI
L30 HL138782 (PI: Karnes)
7/1/17–6/30/22
National Heart, Lung, and Blood Institute (NHLBI)
NIH Loan Repayment Program (Clinical Research LRP) Initial Award and Two Renewals
Role: PI
R21AI152394 (PI: Lussier)
03/06/20–02/28/22
NIH/ National Institute of Allergy and Infectious Disease
Systems-level Genetic Patterns Underlying Disseminated Coccidioidomycosis in Humans
To discover the specific genetic factors associated with DCM pathogenesis, we will conduct genome-wide analyses on the human genetic variants and complex patterns that underlie susceptibility to disseminated coccidioidomycosis.
Role: Scientific Advisor
Flinn Foundation (PIs: Karnes, Heise)
11/1/18-10/31/20
Seed Grant to Promote Translational Research in Precision Medicine
Large-Scale Implementation of Pharmacogenomics: Translating Genotype-Guided Warfarin Dosing from Discovery to the Bedside
Role: Multi-PI
16SDG29090005 (PI: Karnes)
7/1/16–3/31/19 (award returned early due to K01)
American Heart Association/Western States Affiliate
Immunogenetics of Heparin-Induced Thrombocytopenia
The primary purpose of this award was to investigate the influence and interaction of human leukocyte antigen (HLA) alleles and T-cell receptor (TCR) clonotypes on heparin-induced thrombocytopenia.
Role: PI
American College of Clinical Pharmacy (PI: Karnes)
9/15/15–9/14/16
Pharmacogenomics of Heparin-Induced Thrombocytopenia
This ACCP Research Institute Futures Award supports development of research skills among early-career ACCP members with a goal of establishing sustained interest and careers in clinical pharmacy research.
Role: PI
Riken-Pharmacogenomics Research Network (PIs: Karnes and Roden) through Riken Center for Integrative Medical Science.
Awarded September 2017.
Deep Sequencing to Identify Genetic Determinants of Heparin-Induced Thrombocytopenia.
Role: Co-PI
UAHS Career Development Award (PI: Karnes)
9/1/16–8/31/18
Warfarin Pharmacogenetics in Latino Populations
University of Arizona Health Sciences Career Development Award aimed at generating pilot data for discovery of new variants affecting warfarin dose in Latinos.
Role: PI
Riken-Pharmacogenomics Research Network (PGRN) (PIs: Karnes and Roden)
Riken Center for Genomic Medicine.
Awarded May 2015.
Genetic Determinants of Heparin-Induced Thrombocytopenia.
Role: Co-PI
UAHS- Clinical Research Pilot Program Award (PI: Karnes)
7/1/16 – 6/30/17
University of Arizona Health Sciences Clinical Research Pilot Program Award (UAHS-CRPA) aimed at generating pilot data to determine biomarkers for heparin-induced thrombocytopenia (HIT).
Role: PI
15POST22660017 (PI: Karnes)
1/1/15 – 8/31/15
Immunogenetics of Heparin-Induced Thrombocytopenia
This American Heart Association postdoctoral fellowship (Greater Southeast Affiliate) uses BioVU, Vanderbilt’s biorepository coupled to electronic health records, to identify HLA alleles associated with HIT. A clinical study was also proposed to identify TCR clonotypes that predict HIT.
Role: PI
T32GM007569 (PI: Stein)
8/13/12 - 12/31/14
Clinical Pharmacology Fellowship Training Program, Vanderbilt University - funded by the National Institute of Child Health & Human Development and the National Institute of General Medical Sciences.
Role: Awardee
University of Florida CTSI (PI: Cooper-DeHoff)
2009 – 2012
Long Term Antihypertensive Exposure and Adverse Metabolic Effects: PEAR Follow-Up Study
Clinical Research Unit Study #805 aimed at identifying clinical risk factors for long term adverse metabolic effects of thiazide diuretics.
Role: Co-I
J. Craig Venter Institute (PI: Cooper-DeHoff)
2008–2012
Understanding the Relationship of Transcription Factor 7-like Gene (TCF7L2) Polymorphisms and Incidence of Diabetes in an Ethnically Diverse Hypertensive Heart Disease Population
National Institutes of Health NHLBI Resequencing and Genotyping Service Award
Role: Co-I
08/12/2022-07/31/2023
NIH/National Heart, Lung, and Blood Institute
Role: PI
K01HL143137 (PI: Karnes)
04/01/19–06/30/22 (award returned early due to multiple R01s)
NIH/National Heart, Lung, and Blood Institute
Genomic and Transcriptomic Influences on Heparin-Induced Thrombocytopenia
The primary goal of this career development award is to determine the influence of genomic and transcriptomic variation on the development of heparin-induced thrombocytopenia (HIT).
Role: PI
L30 HL138782 (PI: Karnes)
7/1/17–6/30/22
National Heart, Lung, and Blood Institute (NHLBI)
NIH Loan Repayment Program (Clinical Research LRP) Initial Award and Two Renewals
Role: PI
R21AI152394 (PI: Lussier)
03/06/20–02/28/22
NIH/ National Institute of Allergy and Infectious Disease
Systems-level Genetic Patterns Underlying Disseminated Coccidioidomycosis in Humans
To discover the specific genetic factors associated with DCM pathogenesis, we will conduct genome-wide analyses on the human genetic variants and complex patterns that underlie susceptibility to disseminated coccidioidomycosis.
Role: Scientific Advisor
Flinn Foundation (PIs: Karnes, Heise)
11/1/18-10/31/20
Seed Grant to Promote Translational Research in Precision Medicine
Large-Scale Implementation of Pharmacogenomics: Translating Genotype-Guided Warfarin Dosing from Discovery to the Bedside
Role: Multi-PI
16SDG29090005 (PI: Karnes)
7/1/16–3/31/19 (award returned early due to K01)
American Heart Association/Western States Affiliate
Immunogenetics of Heparin-Induced Thrombocytopenia
The primary purpose of this award was to investigate the influence and interaction of human leukocyte antigen (HLA) alleles and T-cell receptor (TCR) clonotypes on heparin-induced thrombocytopenia.
Role: PI
American College of Clinical Pharmacy (PI: Karnes)
9/15/15–9/14/16
Pharmacogenomics of Heparin-Induced Thrombocytopenia
This ACCP Research Institute Futures Award supports development of research skills among early-career ACCP members with a goal of establishing sustained interest and careers in clinical pharmacy research.
Role: PI
Riken-Pharmacogenomics Research Network (PIs: Karnes and Roden) through Riken Center for Integrative Medical Science.
Awarded September 2017.
Deep Sequencing to Identify Genetic Determinants of Heparin-Induced Thrombocytopenia.
Role: Co-PI
UAHS Career Development Award (PI: Karnes)
9/1/16–8/31/18
Warfarin Pharmacogenetics in Latino Populations
University of Arizona Health Sciences Career Development Award aimed at generating pilot data for discovery of new variants affecting warfarin dose in Latinos.
Role: PI
Riken-Pharmacogenomics Research Network (PGRN) (PIs: Karnes and Roden)
Riken Center for Genomic Medicine.
Awarded May 2015.
Genetic Determinants of Heparin-Induced Thrombocytopenia.
Role: Co-PI
UAHS- Clinical Research Pilot Program Award (PI: Karnes)
7/1/16 – 6/30/17
University of Arizona Health Sciences Clinical Research Pilot Program Award (UAHS-CRPA) aimed at generating pilot data to determine biomarkers for heparin-induced thrombocytopenia (HIT).
Role: PI
15POST22660017 (PI: Karnes)
1/1/15 – 8/31/15
Immunogenetics of Heparin-Induced Thrombocytopenia
This American Heart Association postdoctoral fellowship (Greater Southeast Affiliate) uses BioVU, Vanderbilt’s biorepository coupled to electronic health records, to identify HLA alleles associated with HIT. A clinical study was also proposed to identify TCR clonotypes that predict HIT.
Role: PI
T32GM007569 (PI: Stein)
8/13/12 - 12/31/14
Clinical Pharmacology Fellowship Training Program, Vanderbilt University - funded by the National Institute of Child Health & Human Development and the National Institute of General Medical Sciences.
Role: Awardee
University of Florida CTSI (PI: Cooper-DeHoff)
2009 – 2012
Long Term Antihypertensive Exposure and Adverse Metabolic Effects: PEAR Follow-Up Study
Clinical Research Unit Study #805 aimed at identifying clinical risk factors for long term adverse metabolic effects of thiazide diuretics.
Role: Co-I
J. Craig Venter Institute (PI: Cooper-DeHoff)
2008–2012
Understanding the Relationship of Transcription Factor 7-like Gene (TCF7L2) Polymorphisms and Incidence of Diabetes in an Ethnically Diverse Hypertensive Heart Disease Population
National Institutes of Health NHLBI Resequencing and Genotyping Service Award
Role: Co-I